Figure 1. TMM establishes “integrated biobank” consisting of biospecimens, information of cohort studies, and genome-omics analyses. The integrated biobank is an important research infrastructure for implementing genomic medicine.
Figure 2. TMM establishes two cohorts, TMM CommCohort and TMM BirThree Cohort. Taking advantages of these cohorts and their synergistic effects, we provide the reference panel as control data for clinical diagnosis and establish risk prediction scores of complex diseases by gene-environment interaction studies.
Figure 3. Our strategy of genome analyses and target diseases. A whole-genome reference panel is developed by using TMM CommCohort and applied for genotype imputation subsequent to large-scale genotyping by Japonica array™. The TMM BirThree Cohort is utilized for the collection of accurate haplotype information.