Figure 1. RCAN1 (a) and BDNF (b) expression in hippocampi of each group. Both of RCAN1 and BDNF expressions of CFN were significantly higher than those of the control and HFN. Control: High-fat diet with no exercise for 3 months; HFN: high-fat diet with no exercise for 6 months; HFE: high-fat diet with no exercise for 3 months and then with exercise for 3 months; CFN: high-fat diet with no exercise for 3 months and then low-fat diet with no exercise for 3 months; LFN: low-fat diet with no exercise for 6 months. *P < 0.05 vs. control, †P < 0.05 vs. HFN. Error bars represent SD.
Figure 2. Results of the open field test and the novel object recognition test. The % time of center in open field test as locomotor activity (a) and exploration time of novel object recognition as recognition memory (b) in all four groups. The % time of center of HFE was significantly longer than that of control. The exploration time of CFN was significantly longer than that of control.*P < 0.05 vs. control. Error bars represent SD.
