Figure 1. Differences of hemodynamics in patients who underwent neurosurgery and urological surgery between 5-aminolevulinic acid-pretreatment and non-pretreatment.
a), b) and c): Systolic blood pressures, diastolic blood pressures, and heart rates during perioperative courses in patients who underwent neurosurgery. d), e) and f): those in patients who underwent urological surgery.
Data are presented as medians [interquartile range]. ‡, P < 0.01; †, P < 0.05; comparison with baseline values using Wilcoxon signed rank test with Bonferroni adjustment following Friedman test. **, P < 0.01; *, P < 0.05; comparison between the 5-aminolevulinic acid-pretreated and non-pretreated patients using the Mann-Whitney U test.
Abbreviations: Non-pretreated, patients who had no pretreatment before surgery; 5-ALA-pretreated, patients pretreated with 5-aminolevulinic acid; NeuroSRG, neurosurgery (brain tumor resection); TUR, urological surgery (transurethral resection of bladder tumor); TBL, on the early morning of the surgery day (before the pretreatments); T2, before patients entered the operating room (2-2.5 h after the pretreatment, preoperatively); T3, before anesthesia induction (3 h after the pretreatment, preoperatively); T4, amid operation (4 h after the pretreatment, intraoperatively); T6, amid operation in the neurosurgery (6 h after the pretreatment, intraoperatively) and after operation in the urological surgery (6 h after the pretreatment, postoperatively); T9, after operation (9 h after the pretreatment, postoperatively).

From: Differences in 5-Aminolevulinic Acid-Induced Hemodynamic Changes between Patients Undergoing Neurosurgery and Urological Surgery

Figure 2. Kaplan-Meier curves of the cumulative incidence of systolic blood pressure reduction and heart rate elevation from baseline.
a and c) Cumulative incidence of 20% reduction in systolic blood pressure from baseline in patients who underwent neurosurgery and urological surgery. b and d) Cumulative incidence of 20% elevation in heart rate from baseline in patients who underwent neurosurgery and urological surgery.
Abbreviations: Non-pretreated (Non), patients who had no pretreatment before surgery; 5-ALA-pretreated (5-ALA), patients pretreated with 5-aminolevulinic acid; NeuroSRG, neurosurgery (brain tumor resection); TUR, urological surgery (transurethral resection of bladder tumor); SBP, systolic blood pressure; HR, heart rate.

From: Differences in 5-Aminolevulinic Acid-Induced Hemodynamic Changes between Patients Undergoing Neurosurgery and Urological Surgery

Figure 3. 5-Aminolevulinic acid-induced changes in systolic blood pressure from baseline values before patients entered the operating room.
Data are presented as medians [interquartile range]. **, P < 0.01; *, P < 0.05.
Abbreviations: Non-pretreated, patients who had no pretreatment before surgery; 5-ALA-pretreated, patients pretreated with 5-aminolevulinic acid; SBP, systolic blood pressure; NeuroSRG, patients who underwent neurosurgery; TUR, patients who underwent urological surgery.

From: Differences in 5-Aminolevulinic Acid-Induced Hemodynamic Changes between Patients Undergoing Neurosurgery and Urological Surgery

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