Figure 2. Receiver operating characteristic (ROC) analysis of ALT. The sensitivity and specificity of ALT were determined in the study to discriminate patients with NAFL from those with NASH s0-1/NASH s2-3 (1) as well as patients with NASH s0-1/NASH s2-3 from those with NASH s4/LC (2).

From: Positive Pattern Recognition System Using Alanine Aminotransferase, Type IV Collagen 7s, and E Value (Liver Stiffness) for the Diagnosis of Nonalcoholic Steatohepatitis Based on Natural History

Figure 3. (a) Boxplots (median, upper, and lower quartiles, range, and outliers (circles)) of type IV collagen 7s.
A stepwise increase in type IV collagen 7s was observed from NAFL to NASH s4.
Note: (1): P < 0.0013 between NAFL and all NASH
(2): P < 0.0001 between NAFL/NASH s0-1 and NASH s2-3/NASH s4.
(b) Boxplots (median, upper, and lower quartiles, range, and outliers (circles)) of E value. A stepwise increase in E value was observed from NAFL to NASH s4.
Note: P < 0.0001 between NAFL and all NASH.

From: Positive Pattern Recognition System Using Alanine Aminotransferase, Type IV Collagen 7s, and E Value (Liver Stiffness) for the Diagnosis of Nonalcoholic Steatohepatitis Based on Natural History

Table 3. The Case Distributions in the Positive Pattern Recognition System to See the Relationship between Combination Patterns and Histological Classification.

From: Positive Pattern Recognition System Using Alanine Aminotransferase, Type IV Collagen 7s, and E Value (Liver Stiffness) for the Diagnosis of Nonalcoholic Steatohepatitis Based on Natural History

Table 4. Comparison between the Reported Scoring Systems (FIB4 Index, NFS, BARD Score, and NAFIC Score) and ACE Score for NASH Diagnosis.

From: Positive Pattern Recognition System Using Alanine Aminotransferase, Type IV Collagen 7s, and E Value (Liver Stiffness) for the Diagnosis of Nonalcoholic Steatohepatitis Based on Natural History

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