Figure 1. Plain X-ray of both hands shows soft tissue swelling and extensor tenosynovitis without bone erosions.

From: Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome Precedes the Development of Hepatocellular Carcinoma

Figure 2. Contrast-enhanced CT shows that the tumor was hyperdense in the arterial phase (A) and hypodense in the delayed phase (B) images. EOB-MRI shows that the tumor was hyperintense on T2WI (C) and DWI (D) and clearly hypointense in the hepatocyte phase (E).
EOB-MRI, gadoxetic acid-enhanced magnetic resonance imaging; T2WI, T2-weighted image; DWI, diffusion-weighted imaging.

From: Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome Precedes the Development of Hepatocellular Carcinoma

Figure 3. The pathological findings of liver-excised tissues.
(A) The resected specimen. No cirrhosis is observed.
(B) Moderately differentiated hepatocellular carcinoma (HE ×20).
(C) The background liver tissue contained approximately 10% fat and enlargement of the portal tract with mild-to-moderate inflammatory cell infiltration. Bridging fibrosis was not observed (HE ×10).

From: Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome Precedes the Development of Hepatocellular Carcinoma

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