Table 1. Comparison of Short-term Outcomes between Minimally-invasive Esophagectomy and Open Esophagectomy in Population-based Studies.

From: Recent Topics and Perspectives on Esophageal Cancer in Japan

Authors, Year Database* No. of cases** Morbidity Pneumonia Leak SSI Reoperation within 30 days Mortality Hospital stay
% P % P % P % P % P Days P
Mamidanna R, et al., 2012 HES MIE 1155 19.9 0.30 NA NA 8.8 <0.001 4.0 0.61
OE 6347 18.6 5.6 4.3
Takeuchi H, et al., 2014 NCD MIE 1751 15.0 0.60 14.9 0.016 7.8 0.87 8.0 0.001 3.0 0.26 NA
OE 3603 15.5 12.5 7.7 5.6 3.6
Thirunavukarasu P, et al., 2016 NCDB MIE 997 NA NA NA 3.3 0.17 NA
OE 3050 4.3
Sihaq S, et al., 2016 STS MIE 814 NA NA 2.3 <0.001 9.9 <0.001 9 <0.001
OE 2356 6.6 4.4 10
Seesing MFJ, et al., 2017 DUGC, PSM MIE 433 35.6 0.67 21.2 0.028 3.9 0.43 4.7 0.21 13 0.001
OE 433 34.2 15.5 5.1 3.0 14
Takeuchi H, et al., 2017 NCD, PSM MIE 3515 13.9 0.16 12.8 0.86 6.7 0.032 7.0 0.004 2.5 0.41 NA
OE 3515 15.2 12.7 8.1 5.3 2.8
Kauppila JH, et al., 2018 Finland & Sweden MIE 217 NA NA NA 4.1 15
OE 1397 6.8 16
Table 2. Clinical Trials Influenced the Standard Treatment.

From: Recent Topics and Perspectives on Esophageal Cancer in Japan

Study name (year) Histologic subtype* Treatment arms** Main results***
JCOG9204 (2003) SCC Surgery alone 5y-DFS 45% P = 0.037
Surgery + CF 5y-DFS 55%
MAGIC (2006) Esophagogastric AC Surgery alone 5y-OS 23% P = 0.009
ECF + Surgery + ECF 5y-OS 36%
JCOG9907 (2012) SCC Surgery + CF 5y-OS 43% P = 0.04
CF + Surgery 5y-OS 55%
CROSS (2012) SCC, AC Surgery alone Median OS 24.0M P = 0.003
CRT + Surgery Median OS 49.4M
FLOT (2017) Esophagogastric AC ECF or ECX + Surgery + ECF or ECX Median OS 35M P = 0.012
FLOT + Surgery + FLOT Median OS 50M
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