Table 1. Characteristics of the Study Participants.

From: Intermittent Diabetes Care and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus: Findings from Data Analysis of Local Governmental Claims Data

Total sample
(n = 46,450; 100.0%)
No new onset
of diabetic kidney
disease
(n = 44,294; 95.4%)
New onset of
diabetic kidney
disease
(n = 2,156; 4.6%)
n (%)/mean ± SD n (%)/mean ± SD n (%)/mean ± SD
Sex
 Men 25,922 (55.8) 24,610 (55.6) 1,312(60.9)
 Women 20,528 (44.2) 19,684 (44.4) 844 (39.1)
Age
 ≤49 years 1,705 (3.7) 1,632 (3.7) 73 (3.4)
 50-59 years 2,561 (5.5) 2,443 (5.5) 118 (5.5)
 60-69 years 11,824 (25.8) 11,252 (25.4) 572 (26.5)
 70-79 years 19,084 (41.1) 18,195 (41.1) 889 (41.2)
 ≥80 years 11,276 (24.3) 10,772 (24.3) 504 (23.4)
Hypertension
 Yes 35,056 (75.5) 33,376 (75.4) 1,680 (77.9)
 No 11,394 (24.5) 10,918 (24.6) 476 (22.1)
Dyslipidemia
 Yes 32,545 (70.1) 31,006 (70.0) 1,539 (71.4)
 No 13,905 (29.9) 13,288 (30.0) 617 (28.6)
Hyperuricemia
 Yes 6,773 (14.6) 6,375 (14.4) 398 (18.5)
 No 39,677 (85.4) 37,919 (85.6) 1,758 (81.5)
Proportion of outpatient prescription days (%) 76.2 ± 23.9 76.1 ± 24.0 79.6 ± 20.7
 T1 (low prescription: ≤73.96%) 15,431 (33.2) 14,820 (33.5) 611 (28.3)
 T2 (moderate prescription: 73.97-92.05%) 13,950 (30.0) 13,219 (29.8) 731 (33.9)
 T3 (high prescription: ≥92.06%) 17,069 (36.7) 16,255 (36.7) 814 (37.8)
Table 2. Adjusted Hazard Ratios of Risk Factors for Diabetic Kidney Disease.

From: Intermittent Diabetes Care and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus: Findings from Data Analysis of Local Governmental Claims Data

Total sample Excluding those with
a proportion of outpatient
prescription days of <50%
aHR (95% CI) aHR (95% CI)
Sexa Men 1.22 (1.12-1.34) 1.19 (1.08-1.31)
Ageb 50-59 years 1.05 (0.79-1.41) 1.02 (0.73-1.42)
60-69 years 1.10 (0.86-1.40) 1.07 (0.81-1.42)
70-79 years 1.08 (0.85-1.37) 1.09 (0.83-1.43)
≥80 years 1.14 (0.89-1.47) 1.13 (0.85-1.50)
Hypertensionc Yes 1.13 (1.02-1.25) 1.12 (1.00-1.25)
Dyslipidemiad Yes 1.02 (0.92-1.12) 1.01 (0.92-1.12)
Hyperuricemiae Yes 1.27 (1.13-1.42) 1.27 (1.13-1.43)
Proportion of outpatient prescription daysf T1 (low prescription: ≤73.96%) 0.84 (0.75-0.93) 1.05 (0.93-1.19)
T2 (moderate prescription: 73.97-92.05%) 1.01 (0.92-1.12) 1.01 (0.92-1.12)
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