Table 1. Laboratory Data at the Time of Diagnosis.

From: Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome Precedes the Development of Hepatocellular Carcinoma

Laboratory test
(Reference value)
Diagnosis of
RS3PE syndrome
Diagnosis of HCC
Leukocytes (3900-9800/μL) 3900/μL 5500/μL
Hemoglobin (13.4-17.6 g/dL) 13.6 g/dL 13.8 g/dL
Platelets (15-40 *104/μL) 17.4*104/μL 17.1*104/μL
Albumin (4.1-5.1 g/dL) 2.5 g/dL 3.7 g/dL
Total bilirubin (0.2-1.2 mg/dL) 0.5 mg/dL 0.6 mg/dL
AST (13-30 U/L) 33 U/L 22 U/L
ALT (10-42 U/L) 32 U/L 16 U/L
CRP (0.00-0.30 mg/dL) 9.67 mg/dL 0.24 mg/dL
ESR (0-10 mm/h) 36 mm/h Not measured
Ferritin (18-250 ng/mL) 503.3 ng/mL Not measured
PT activation (80%-100%) 85.9% 87.6%
AFP (<10 ng/mL) Not measured 1.7 ng/mL
PIVKA-II (<40 mAU/mL) Not measured 23 mAU/mL
IgG (815-1800 mg/dL) 1449 mg/dL 1553 mg/dL
IgM (32-190 mg/dL) 54 mg/dL 88 mg/dL
RF (0-15 IU/mL) <5 IU/mL Not measured
ANA (negative) 320 Not measured
Anti-CCP (0.0-4.4 U/mL) 1.0 U/mL Not measured
PR3-ANCA (0.0-3.4 EU) <1.0 EU Not measured
MPO-ANCA (0.0-3.4 EU) <1.0 EU Not measured
Hyaluronic acid (≤50.0 ng/mL) Not measured 56.0 ng/mL
M2BPGi (<1.00) Not measured 1.27
7S domain of type IV collagen (≤4.4 ng/mL) Not measured 5.4 ng/mL
Fib-4 index (<1.3 points) 2.41 points 2.48 points
Table 2. Changes in Serum Levels of VEGF, TNF-α, and MMP-3.

From: Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome Precedes the Development of Hepatocellular Carcinoma

Laboratory test
(Reference value)
At the time
of diagnosis of RS3PE
At the time
of diagnosis of HCC
Post-operation of HCC
VEGF (≤38.3 pg/mL) Not measured 141 pg/mL 158 pg/mL
MMP (36.9-121 ng/mL) Not measured 380 ng/mL 51.5 ng/mL
TNF-α (0.75-1.66 pg/mL) Not measured 10.4 pg/mL 11.7 pg/mL
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