Figure and Table | Chronic Recurrent Multifocal Osteomyelitis Associated in a Child with Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Case Report

Table 1. Bristol Diagnostic Criteria for CRMO.

From: Chronic Recurrent Multifocal Osteomyelitis Associated in a Child with Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Case Report

The presence of typical clinical findings (bone pain +/- localised swelling without significant local or systemic features of inflammation or infection)

AND

The presence of typical radiological findings (plain x-ray: showing combination of lytic areas, sclerosis and new bone formation or preferably STIR MRI: showing bone marrow oedema +/- bone expansion, lytic areas and periosteal reaction)

AND EITHER

Criterion 1: more than one bone (or clavicle alone) without significantly raised CRP (CRP < 30 g/L).

Criterion 2: if unifocal disease (other than clavicle), or CRP >30 g/L, with bone biopsy showing inflammatory changes (plasma cells, osteoclasts, fibrosis or sclerosis) with no bacterial growth whilst not on antibiotic therapy.

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