Table 1. Hematologic, Biochemical, and Immunological Findings Obtained after Hepatic Artery Aneurysm Rupture and at 6-Month Follow-Up.

From: Ruptured Hepatic Artery Aneurysms Revealing Systemic Lupus Erythematosus

Parameter Reference range After rupture (Day 10) 6 months follow-up
White blood cell count (/μL) 3,300-8,600 10,520 6,510
Hemoglobin (g/dL) 11.6-14.8 8.0 10.0
Platelet count (/μL) 158,000-348,000 292,000 398,000
Lactate dehydrogenase (U/L) 124-222 151 195
Haptoglobin (mg/dL) 20-200 <1 127
Direct Coombs test Negative Positive NA
Serum creatinine (mg/dL) 0.6-1.1 0.75 0.45
Estimated glomerular filtration rate (mL/min/1.73 m2) >60 57.1 99.5
Proteinuria (g/g creatinine) <0.15 0.79 0.31
Aspartate aminotransferase (U/L) 13-30 46 11
Alanine aminotransferase (U/L) 7-23 26 4
Alkaline phosphatase (U/L) 38-113 122 62
Gamma-glutamyl transpeptidase (U/L) 9-32 82 29
Total bilirubin (mg/dL) 0.4-1.5 0.34 0.32
Complement component 3 (mg/dL) 86-160 67 126
Complement component 4 (mg/dL) 17-45 10 17
Total hemolytic complement activity (CH50/mL) 25-48 13.1 22.9
Anti-double-stranded DNA antibody Negative Positive Negative
Lupus anticoagulant Negative Positive NA
Anti-cardiolipin β2 glycoprotein I antibody Negative Positive NA
Proteinase 3-anti-neutrophil cytoplasmic antibody (U/mL) <3.4 <1 NA
Myeloperoxidase-anti-neutrophil cytoplasmic antibody (U/mL) <3.5 <1 NA
Antinuclear antibody, Homogeneous pattern (titer) <1:40 80 NA
Antinuclear antibody, Speckled pattern (titer) <1:40 80 NA
Antinuclear antibody, Nucleolar pattern (titer) <1:40 80 NA
C-reactive protein (mg/dL) <0.14 5.01 1.48
Table 2. Reported Cases of Hepatic Artery Aneurysm Associated with Systemic Lupus Erythematosus.

From: Ruptured Hepatic Artery Aneurysms Revealing Systemic Lupus Erythematosus

Author & Year Age / Sex Chief Complaint / Presentation Aneurysm Location Treatment Method Outcome Reference
C Liu, 2011 31-year-old male Epigastric pain and jaundice for 2 months Two hepatic artery aneurysms in the left lateral lobe TAE, later left lateral lobectomy and ligation of the proximal hepatic artery Good recovery 7
EN Pollono, 2009 56-year-old female Gastrointestinal bleeding without identifiable lesions Multiple hepatic artery aneurysms TAE Good recovery 4
J Trambert, 1989 49-year-old male Caused by ruptured aneurysms of a branch of the left hepatic artery Branch of the left hepatic artery TAE Good recovery 8
Present case, 2022 74-year-old female Abdominal pain, intraperitoneal bleeding Multiple intrahepatic aneurysms TAE Good recovery
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