| Characteristic | Value | All patients (n = 216) |
|---|---|---|
| Median age, years (range) | 40.5 (10-79) | |
| Sex, females/males, n (%) | 47 (21.8) : 169 (78.2) | |
| CDAI, average | 104.4 ± 71.7 | |
| Montreal classification, n (%) | ||
| Age at diagnosis, A1 : A2 : A3 | 34 (15.7) : 163 (75.5) : 19 (8.8) | |
| Location, L1 : L3 | 89 (41.2) : 127 (58.8) | |
| Behavior, B1 : B2 : B3 | 56 (25.9) : 96 (44.4) : 64 (29.6) | |
| mSES-CD, average | 3.96 ± 2.80 | |
| 0-2, n (%) | 56 (25.9) | |
| 3-4, n (%) | 60 (27.8) | |
| 5-6, n (%) | 60 (27.8) | |
| 7-9, n (%) | 40 (18.5) | |
| Biomarkers, median (range) | ||
| LRG, μg/mL | 15.9 (5.8-61.9) | |
| Leukocyte count, /μL | 5,020 (2080-14,560) | |
| Neutrophil count, /μL | 3,110 (970-12,940) | |
| Hemoglobin, g/dL | 13.4 (7.5-16.9) | |
| Platelet count, 10^4/μL | 28.1 (3.9-68.4) | |
| CRP, mg/dL | 0.14 (0-12.6) | |
| ESR, mm/h | 13 (2-99) | |
| Albumin, g/dL | 4.0 (1.7-5.0) |
| Biomarker | AUC (95% CI) | Sensitivity (%, 95% CI) | Specificity (%, 95% CI) |
|---|---|---|---|
| LRG (μg/mL) | 0.906 (0.863-0.949) | 72.1 (64.0-78.9) | 93.7(86.2-97.3) |
| Leukocyte(/μL) | 0.503 (0.422-0.584) | 59.6 (51.2-67.4) | 46.3 (35.7-57.1) |
| Neutrophil (/μL) | 0.620 (0.542-0.698) | 11.8 (7.4-18.3) | 97.5 (91.3-99.6) |
| Hemoglobin (g/dL) | 0.633 (0.558-0.708) | 16.2 (10.9-23.3) | 98.8 (93.3-99.9) |
| Platelet (10^4/μL) | 0.594 (0.512-0.675) | 8.1 (4.6-13.9) | 95.0 (87.8-98.0) |
| CRP (mg/dL) | 0.776 (0.713-0.839) | 14.0 (9.1-20.8) | 98.8 (93.3-99.9) |
| ESR (mm/h) | 0.679 (0.606-0.753) | 6.6 (3.5-12.1) | 98.8 (93.3-99.9) |
| Albumin (g/dL) | 0.785 (0.724-0.846) | 6.6 (3.5-12.1) | 98.8 (93.3-99.9) |
| CDAI | 0.734 (0.668-0.800) | 6.6 (3.5-12.1) | 98.8 (93.3-99.9) |
| Variable | OR | (95% CI) | p-Value |
|---|---|---|---|
| Age (+1 year) | 1.00 | (0.97-1.03) | 0.834 |
| Female (vs male) | 1.27 | (0.41-3.92) | 0.684 |
| Body Mass Index (+1 kg/m2) | 1.07 | (0.94-1.22) | 0.304 |
| LRG ≥ cutoff value (vs < cutoff value) | 36.40 | (10.08-131.47) | <0.001 |
| Leukocyte (+1,000 /μL) | 0.38 | (0.21-0.67) | 0.001 |
| Neutrophil (+1,000 /μL) | 2.91 | (1.55-5.46) | 0.001 |
| Hemoglobin (+1 g/dL) | 1.05 | (0.80-1.38) | 0.718 |
| Platelet (+10^4/μL) | 1.00 | (0.94-1.06) | 0.992 |
| CRP (+1 mg/dL) | 1.35 | (0.37-4.94) | 0.651 |
| ESR (+1 mm/h) | 0.99 | (0.95-1.04) | 0.813 |
| Albumin (+1 g/dL) | 0.94 | (0.68-1.30) | 0.699 |
| CDAI (+10) | 1.12 | (1.02-1.23) | 0.016 |
