| Parameter | Hot flashes | Total (n = 180) | p-Value | |
|---|---|---|---|---|
| Onset (n = 99) | Non-onset (n = 81) | |||
| Age, years | 76 (70-79) | 77 (74-82) | 76 (72-80) | 0.019 |
| Height, cm | 167.0 (163.0-170.0) | 164.9 (160.0-167.9) | 165.5 (162.0-169.9) | 0.004 |
| Weight, kg | 67.0 (60.0-71.2) | 60.0 (54.0-69.0) | 64.4 (57.0-70.6) | 0.003 |
| BMI | 23.3 (22.1-25.9) | 22.7 (20.8-25.4) | 23.1 (21.2-25.7) | 0.069 |
| Initial PSA, ng/mL | 15.7 (8.2-51.0) | 16.7 (8.3-44.7) | 15.8 (8.3-47.0) | 0.570 |
| Prostate volume, mL | 33.6 (22.9-47.7) | 21.2 (25.0-43.8) | 32.4 (24.2-45.2) | 0.983 |
| Smoking | ||||
| Yes | 15 (15.3) | 12 (15.0) | 27 (15.2) | 1.000 |
| No | 83 (84.7) | 68 (85.0) | 151 (84.8) | |
| Hormonal therapy | ||||
| LH-RH agonist | 75 (75.8) | 54 (66.7) | 129 (71.7) | 0.188 |
| LH-RH antagonist | 24 (24.2) | 27 (33.3) | 51 (28.3) | |
| Combined androgen blockade | 92 (92.9) | 71 (87.7) | 163 (90.5) | 0.212 |
| TNM-based grouping | ||||
| N0M0 | 64 (64.6) | 54 (66.7) | 118 (65.6) | 0.875 |
| N1 or M1 | 35 (35.4) | 27 (33.3) | 62 (34.4) | |
| Gleason score | 8 (7-9) | 8 (7-9) | 8 (7-9) | 0.704 |
| Comorbidity | ||||
| Heart failure | 9 (9.1) | 13 (16.0) | 22 (12.2) | 0.176 |
| Ischemic heart disease | 16 (16.2) | 13 (16.0) | 29 (16.1) | 1.000 |
| Hypertension | 52 (52.5) | 44 (54.3) | 96 (53.3) | 0.881 |
| Atrial fibrillation | 4 (4.0) | 17 (21.0) | 21 (11.7) | 0.001 |
| Diabetes | 17 (17.2) | 12 (14.8) | 29 (16.1) | 0.690 |
| Drugs for cardiovascular diseases | ||||
| Beta-blockers | 11 (11.1) | 26 (32.1) | 37 (20.6) | 0.001 |
| RAS inhibitors | 40 (40.4) | 37 (45.7) | 77 (42.7) | 0.545 |
| Calcium channel blockers | 47 (47.5) | 37 (45.7) | 84 (46.7) | 0.881 |
| Nitrate drugs | 6 (6.1) | 3 (3.7) | 9 (5.0) | 0.517 |
| Other drugs | ||||
| Steroids | 2 (2.0) | 1 (1.2) | 3 (1.7) | 1.000 |
| Anticonvulsants | 1 (1.0) | 0 (0) | 1 (0.6) | 1.000 |
| Herbal medicines | 4 (4.0) | 2 (2.5) | 6 (3.3) | 0.692 |
| Antidepressants | 0 (0) | 1 (1.2) | 1 (0.6) | 0.450 |
| Dopamine agonists | 0 (0) | 0 (0) | 0 (0) | - |
| Independent variables | Hot flashes | ||
|---|---|---|---|
| OR (95% CI) | P-value | ||
| Younger | 1.056 (1.004-1.110) | 0.034 | |
| High BMI | 0.917 (0.820-1.020) | 0.110 | |
| Cardiovascular disease | Heart failure | 2.090 (0.560-7.820) | 0.272 |
| Atrial fibrillation | 0.257 (0.071-0.928) | 0.038 | |
| Therapeutic drugs | Beta-blockers | 0.265 (0.086-0.816) | 0.021 |
| RAS inhibitors | 0.826 (0.407-1.670) | 0.595 | |
| Calcium channel blockers | 1.310 (0.660-2.610) | 0.439 | |
| Nitrate drugs | 2.060 (0.434-9.750) | 0.364 | |
