Table 1. 1,291 Participants’ Characteristics Stratified by Use of Sleeping Medications.

From: Sleeping Medications and Prevention of Functional Disability in Older Adults with Low Care Needs: A Prospective Cohort Study

Sleeping medications p-Value
Baseline characteristics No use Use
n 923 368
Age, year 80 (74-84) 80 (76-84) 0.404
Men, n (%) 293 (31.7) 133 (36.1) 0.147
Baseline care levels, n (%)
 Requiring support 1 640 (69.3) 239 (64.9) 0.144
 Requiring support 2 283 (30.7) 129 (35.1) <0.001
Antianxiety drugs, n (%) 113 (12.2) 127 (34.5) <0.001
Antidepression drugs, n (%) 25 (2.7) 34 (9.2) <0.001
Acetaminophen, n (%) 23 (2.5) 18 (4.9) <0.001
Antidiabetic drugs, n (%) 108 (11.7) 76 (20.7) <0.001
Antiplatelet drugs, n (%) 229 (24.8) 163 (44.3) <0.001
Beta-blockers, n (%) 67 (7.3) 63 (17.1) <0.001
Calcium channel blockers, n (%) 305 (33.0) 198 (53.8) <0.001
RAS blockers, n (%) 268 (29.0) 150 (40.8) <0.001
Cholesterol-lowering drugs, n (%) 190 (20.6) 111 (30.2) <0.001
Antidementia drugs, n (%) 68 (7.4) 31 (8.4) 0.597
Kidney replacement therapy, n (%) 8 (0.9) 10 (2.7) 0.022
Region, n (%)
 Izumi city 619 (67.1) 235 (63.9)
 Izumiotsu city 224 (24.3) 107 (29.1)
 Misaki town 80 (8.7) 26 (7.1)
Table 2. Associations Between the Sleeping Medications and the Incidence of Functional Disabilities.

From: Sleeping Medications and Prevention of Functional Disability in Older Adults with Low Care Needs: A Prospective Cohort Study

All participants PS-matched participants
Sleeping medications Sleeping medications
Variables No use Use No use Use
Number 923 368 332 332
Observational period, year 2.6 (1.2-3.0) 2.4 (0.8-3.0) 2.6 (1.4-3.0) 2.5 (0.9-3.0)
Incidence of functional disabilities, n (%) 504 (54.6) 183 (49.7) 197 (59.3) 157 (47.3)
All-cause mortality, n (%) 91 (9.9) 60 (16.3) 29 (8.7) 56 (16.9)
Model 1, SHR (95% CI)* 1.00 (reference) 0.96 (0.80-1.15) 1.00 (reference) 0.82 (0.66-1.03)
Model 2, SHR (95% CI)† 1.00 (reference) 0.91 (0.75-1.10)
Model 3, SHR (95% CI)‡ 1.00 (reference) 0.85 (0.70-1.03)
Model 4, SHR (95% CI)§ 1.00 (reference) 0.82 (0.68-0.99)
PAGE TOP