Figure and Table | Survival Impact of Preoperative Hemoglobin-to-Red Cell Distribution Width Ratio in Stage I Gastric Cancer Treated with Curative Surgery

Table 1. Associations between Preoperative HRR and Clinicopathological Factors.

Variables	#	HRR Median (IQR)	p-Value
Total	120	0.29 (0.23-0.31)
Age at surgery (years)
≤ 69	39	0.30 (0.24-0.32)	0.020^*
≥ 70	81	0.27 (0.22-0.31)	0.020^*
Gender
Male	85	0.28 (0.23-0.31)	0.98
Female	35	0.29 (0.22-0.32)	0.98
ASA-PS
1-2	99	0.29 (0.24-0.32)	0.003^*
3	21	0.22 (0.20-0.29)	0.003^*
Main histology
Intestinal	75	0.28 (0.23-0.32)	0.72
Diffuse	45	0.29 (0.24-0.31)	0.72
Main location
Upper/middle third	32	0.28 (0.21-0.30)	0.32
Lower third	88	0.29 (0.24-0.32)	0.32
Type of gastrectomy
Partial	108	0.29 (0.24-0.32)	0.080
Total	12	0.27 (0.19-0.29)	0.080
Surgical approach
Open	87	0.27 (0.22-0.31)	0.032^*
Laparoscopic/robotic	33	0.30 (0.27-0.32)	0.032^*
Preoperative ER
Absent	98	0.27 (0.22-0.31)	0.17
Present	22	0.30 (0.26-0.31)	0.17
pT classification
T1	98	0.29 (0.24-0.31)	0.63
T2	22	0.27 (0.22-0.32)	0.63
pN classification
N0	116	0.29 (0.23-0.31)	0.75
N1	4	0.28 (0.25-0.34)	0.75
Lymphovascular involvement
Absent	85	0.29 (0.23-0.32)	0.69
Present	35	0.28 (0.24-0.31)	0.69
Postoperative complications
Absent	106	0.29 (0.23-0.32)	0.92
Present	14	0.29 (0.22-0.31)	0.92

Table 2. Univariate Cox Regression Analyses for Overall Survival.

Variables	Overall survival
Variables	HR (95% CI)	p-Value
Age at surgery (≥ 70 years)	4.69 (1.38-15.9)	0.013^*
Gender (male)	2.20 (0.75-6.41)	0.15
ASA-PS (3)	1.22 (0.46-3.28)	0.69
Main histology (intestinal)	1.86 (0.78-4.46)	0.16
Main location (upper/middle third)	2.98 (1.34-6.59)	0.007^*
Type of gastrectomy (total)	2.92 (1.09-7.81)	0.033^*
Surgical approach (open)	1.59 (0.54-4.67)	0.40
Preoperative ER (present)	1.01 (0.30-3.42)	0.99
pT classification (T2)	2.11 (0.87-5.13)	0.098
pN classification (N1)	1.17 (0.16-8.77)	0.88
Lymphovascular involvement (present)	1.67 (0.71-3.94)	0.24
Postoperative complications (present)	2.52 (0.94-6.74)	0.065
Preoperative PNI (≤45)	4.84 (2.16-10.8)	< 0.001^*
Preoperative PNI (per 1-unit decrease)	1.10 (1.04-1.16)	< 0.001^*
Preoperative HRR (≤0.183)	8.75 (3.47-22.1)	< 0.001^*
Preoperative HRR (per 0.1-unit decrease)	4.37 (2.04-9.72)	< 0.001^*

Table 3. Multivariate Cox Regression Analyses for Overall Survival.

Variables	Overall survival
Variables	HR (95% CI)^*	p-Value	AIC
Preoperative PNI (≤45)	4.32 (1.71-10.9)	0.002^†	184.2
Preoperative PNI (per 1-unit decrease)	1.09 (1.01-1.16)	0.013^†	188.3
Preoperative HRR (≤0.183)	8.87 (2.84-27.7)	<0.001^†	181.5
Preoperative HRR (per 0.1-unit decrease)	4.32 (1.79-11.0)	0.001^†	183.1