JMA Journal

Figure 1. Results of the systematic search and study selection process.
*Indicates the PubMed, Cochrane CENTRAL, and Ichusi databases.
A total of 9987 studies were included: 3969 from PubMed, 5919 from Cochrane CENTRAL, and 99 from Ichusi.

Figure 2. Forest plots of saturated fatty acid reduction trials on cardiovascular mortality.
No statistically significant reduction was noted.
CI: confidence interval; OR: odds ratio.

Figure 3. Forest plots of saturated fatty acid reduction trials on all-cause mortality.
No statistically significant reduction was noted.
CI: confidence interval; OR: odds ratio.

Figure 4. Forest plots of saturated fatty acid reduction trials on myocardial infarction.
No statistically significant reduction was noted.
CI: confidence interval; OR: odds ratio.

Figure 5. Forest plots of saturated fatty acid reduction trials on any coronary artery event.
No statistically significant reduction was noted.
CI: confidence interval; OR: odds ratio.

Figure 6. Relationship between the reduction in SFA intake and RRR of each outcome.
No association suggesting dose dependency was observed between the differential of SFA (x axis) (%) and RRR of each outcome (y axis).
CVD: cardiovascular disease; MI: myocardial infarction; RRR: relative risk reduction; SFA: saturated fatty acid.

Figure 7. Relationship between the reduction in saturated fatty acid intake and ARR of each outcome.
No association suggesting dose dependency was observed between the differential of SFA (x axis) (%) and ARR of each outcome (y axis).
ARR: absolute risk reduction; CVD: cardiovascular disease; MI: myocardial infarction.

Figure 8. Relationship between study duration (x axis) and RRR or ARR of each outcome (y axis). According to Pearson’s product-moment correlation analysis, no association between study duration and RRR [upper 4 panels: a)-d)] or ARR [lower 4 panels: e)-h)] was observed.
ARR: absolute risk reduction; CVD: cardiovascular disease; MI: myocardial infarction; RRR: relative risk reduction.

Figure 9. Funnel plots of saturated fatty acid reduction trials on cardiovascular mortality.
No publication bias was noted.

Figure 10. Funnel plots of saturated fatty acid reduction trials on all-cause mortality.
No publication bias was noted.