JMA Journal

Figure 1. Kaplan-Meier survival curves for the overall survival after pancreatectomy in patients with pancreatic cancer, according to the preoperative 6-min walk distance. Kaplan-Meier survival curve showing survival probability based on a 6MWD cut-off of 400 m. The dashed line represents patients with a 6MWD of ≥400 m, whereas the solid line represents those with a 6MWD <400 m. 6MWD, 6-minute walk distance.

Figure 2. Kaplan-Meier analysis of survival rates in patients with pancreatic cancer, stratified by risk categories based on the CCI. Survival rates of patients with pancreatic cancer are categorized by the CCI: low, middle, and high. Patients with a high CCI had significantly lower survival rates compared to those in the other groups (p < 0.05). CCI, Charlson Comorbidity Index.

Figure 3. Kaplan-Meier survival curves for the overall survival after pancreatectomy in patients with pancreatic cancer, according to the preoperative 6MWD-CCI. Survival rates of patients with pancreatic cancer stratified by a combination of 6MWD and the CCI. Patients in the high group demonstrated significantly lower survival rates than those in other groups (p < 0.05). 6MWD, 6-minute walk distance; CCI, Charlson Comorbidity Index.

Figure 4. Predictive performance comparison by time-dependent AUC: 6MWD-CCI composite versus individual components (multivariable-adjusted). Multivariable ROC curves show the predictive performance of 6MWD-CCI, 6MWD, and CCI after adjustment for age, sex, and clinical stage. The composite 6MWD-CCI score demonstrated the highest discriminative ability (AUC=0.785, 95% CI XX-XX), followed by CCI (AUC=0.726) and 6MWD alone (AUC=0.701). 6MWD, 6-minute walk distance; AUC, area under the curve; CI, confidence interval; CCI, Charlson Comorbidity Index.

Figure 5. proposed Nomogram for predicting 1-year and 2-year survival probability of patients with pancreatic cancer. 6MWD-CCI, the combination of 6MWD and CCI. Nomogram incorporating 6MWD, CCI, and other patient characteristics to calculate individual and total scores. The graph highlights the significant impact of 6MWD-CCI on survival rates, as shown by its contribution to the total score. 6MWD, 6-minute walk distance; CCI, Charlson Comorbidity Index.