Figure and Table | Comparison of Recommendations Made by Committee Members with and without Financial Conflict of Interest on Japanese Guideline of Treatment of Hyperuricemia and Gout, Third Edition

Table 1.

CQ (A): Can urate-lowering agents be recommended in patients with hyperuricemia and kidney injury over non-medication treatment?
Recommendation	Direction and strength of the recommendation	Certainty in evidence
The use of urate-lowering agents to retard the decline in kidney function is conditionally recommended in patients with hyperuricemia and kidney injury.	It is conditionally recommended for.	B (moderate)
CQ (B): Can urate-lowering agents be recommended for hypertensive patients with hyperuricemia over non-medication treatment?
Recommendation	Direction and strength of recommendation	Certainty in evidence
The use of urate-lowering agents to improve life prognosis and reduce the risk of cardiovascular disease cannot be actively recommended for hypertensive patients with hyperuricemia	It is conditionally recommended against.	D (very weak)
CQ (C): Can urate-lowering agents be recommended for patients with heart failure and hyperuricemia over non-medication treatment?
Recommendation	Direction and strength of recommendation	Certainty in evidence
The use of urate-lowering agents to improve life prognosis and reduce the risk of cardiovascular disease cannot be actively recommended for patients with heart failure and hyperuricemia.	It is conditionally recommended against.	C (weak)

Table 2.

			Direction and strength of recommendation
CQ A		Total	Recommended against	Conditionally recommended against	Conditionally recommended for	Recommended for
	COI (−)	18	0	1 (5.6%)	17(94.4%)	0
	COI (+)	8	0	1(12.5%)	7(87.5%)	0
			Direction and strength of recommendation
CQ B		Total	Recommended against	Conditionally recommended against	Conditionally recommended for	Recommended for
	COI (−)	18	2 (11.1%)	14 (77.8%)	2 (11.1%)	0
	COI (+)	8	3 (37.5%)	5 (62.5%)	0	0
			Direction and strength of recommendation
CQ C		Total	Recommended against	Conditionally recommended against	Conditionally recommended for	Recommended for
	COI (−)	18	2 (11.1%)	15 (83.3%)	1 (5.6%)	0
	COI (+)	8	4 (50%)	4 (50%)	0	0