Table 1. MTX-HOPE Protocol.

From: Methotrexate, Hydrocortisone, Vincristine, Sobuzoxane, and Etoposide Is an Effective Option for Relapsed T-cell Prolymphocytic Leukemia with Loss of CD52 Expression after Retreatment with Alemtuzumab

Agent Dose/day Route Days of administration
Methotrexate (MTX) 20 mg po 1
Hydrocortisone (HC) 100 mg div (15min) 2
Vincristine (VCR) 1 mg div (15min) 2
Sobuzoxane (MST-16) 400 mg po 3, 4
Etoposide (ETP) 25 mg po 3, 4
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