From: Design, Rational, and Baseline Characteristics of the SONIC-HF Multicenter Registry
| N | Median (IQR); n (%) | |
|---|---|---|
| Age, years | 692 | 81.0 (74.0 - 86.0) |
| Male | 691 | 293 (42.4%) |
| Current smoker | 690 | 62 (9.0%) |
| Body mass index, kg/m2 | 627 | 21.1 (19.0 - 23.7) |
| Body surface area, m2 | 627 | 1.51 (1.37 - 1.64) |
| Systolic blood pressure, mmHg | 690 | 112.0 (102.0 - 124.8) |
| Diastolic blood pressure, mmHg | 690 | 61.0 (56.0 - 68.0) |
| Heart rate, bpm | 690 | 70 (61 - 80) |
| NYHA class III-IV | 685 | 136 (19.9%) |
| Past medical history | ||
| Previous HF hospitalization | 691 | 351 (50.8%) |
| Hypertension | 691 | 442 (64.0%) |
| Diabetes mellitus | 691 | 285 (41.2%) |
| Dyslipidemia | 690 | 247 (35.8%) |
| Peripheral artery disease | 690 | 49 (7.1%) |
| Atrial fibrillation | 691 | 332 (48.0%) |
| Chronic obstructive pulmonary disease | 691 | 71 (10.3%) |
| Stroke or transient ischemic attack | 691 | 80 (11.6%) |
| Coronary artery disease | 690 | 264 (38.3%) |
| Cirrhosis | 691 | 13 (1.9%) |
| Malignancy | 691 | 84 (12.2%) |
| Echocardiography | ||
| LVEF, % | 647 | 45.0 (31.9 - 60.0) |
| LVEF categories, % | 647 | |
| HFpEF | 272 (42.0%) | |
| HFmrEF | 104 (16.1%) | |
| HFrEF | 271 (41.9%) | |
| Significant mitral regurgitation | 646 | 287 (44.4%) |
| Significant aortic regurgitation | 642 | 112 (17.4%) |
| Significant aortic stenosis | 628 | 56 (8.9%) |
| Prescriptions | ||
| Loop diuretics | 691 | 590 (85.4%) |
| Tolvaptan | 691 | 226 (32.7%) |
| ACE inhibitors or ARBs | 691 | 386 (55.9%) |
| Beta-blockers | 691 | 447 (64.7%) |
| MRAs | 691 | 319 (46.2%) |
| Digitalis | 691 | 23 (3.3%) |
| Laboratory data | ||
| Hemoglobin, g/dL | 689 | 11.5 (10.3 - 13.1) |
| Creatinine, mg/dL | 692 | 1.21 (0.96 - 1.72) |
| eGFR, mL/min/1.73m2 | 691 | 45.8 (29.7 - 63.4) |
| Blood urea nitrogen, mg/dL | 692 | 27.0 (20.0 - 38.8) |
| Albumin, g/dL | 655 | 3.50 (3.10 - 3.80) |
| Sodium, mmol/L | 692 | 139.0 (136.0 - 141.0) |
| Potassium, mmol/L | 692 | 4.3 (4.0 - 4.7) |
| Hemoglobin A1c, % | 465 | 6.0 (5.7 - 6.7) |
| BNP, pg/mL | 531 | 235 (122 - 481) |
| NT pro-BNP, pg/mL | 126 | 2,168 (900 - 3,306) |
| MAGGIC score | 584 | 27.0 (23.0 - 31.0) |
From: Design, Rational, and Baseline Characteristics of the SONIC-HF Multicenter Registry
| N | Median (IQR); n (%) | |
|---|---|---|
| Bicep thickness at rest, mm | 606 | 19.6 (15.9 - 23.1) |
| Bicep thickness during contraction, mm | 604 | 25.3 (21.3 - 29.5) |
| Rectus femoris thickness at rest, mm | 604 | 9.7 (7.1 - 12.3) |
| Rectus femoris thickness during contraction, mm | 603 | 12.1 (9.6 - 15.0) |
| Quadriceps thickness at rest, mm | 606 | 19.0 (15.0 - 23.5) |
| Quadriceps thickness during contraction, mm | 605 | 24.8 (19.9 - 29.5) |
| Diaphragm thickness at rest, mm | 605 | 1.88 (1.55 - 2.30) |
| Diaphragm thickness during inspiration, mm | 606 | 2.90 (2.25 - 3.75) |
