Figure and Table | Development of the World’s First In Vitro Cancer Epigenome Diagnostic through Biomarker Research for Personalized Cancer Treatment of RAS-wild-type Colorectal Cancer -Secondary Publication - Secondary Publication

Table 1. Prediction of EGFR Antibody Drug Efficacy Using Whole-Genome Methylation Status and the EpiLight Test.

Detection method for DNA methylation	Treatment line	Patient number	DNA methylation status	Response rate (%)	P value	PFS (M)	P value	OS (M)	P value	Multivariate analyses for PFS and OS
Detection method for DNA methylation	Treatment line	Patient number	DNA methylation status	Response rate (%)	P value	PFS (M)	P value	OS (M)	P value	references
Bead Chip method	3^rd-line	97	HMCC	3.7	0.01	2.3	<0.001	8.5	<0.001	Independent predictive factor
			LMCC	37.9		6.6		20.9		5
	1^st -line	169	HMCC	53.3	0.017	5.7	0.004	31.1	0.019	Independent predictive factor
			LMCC	81.8		13.1		51.4		6
EpiLight method	3^rd-line	101	HMCC	4.2	<0.001	2.5	<0.001	6.6	<0.001	Independent predictive factor
			LMCC	33.3		5.6		11.8		7
	2^nd-line	112	HMCC	0	0.02	1.4	<0.001	6.0	0.11^*	Independent predictive factor
			LMCC	26.6		4.1		11.8		8
	1^st -line	137	HMCC	42.9	0.128^*	4.0	<0.001	13.6	<0.001	Independent predictive factor
			LMCC	71.2		14.3		42.7		9