Figure and Table | Effect of Baseline Values of Renal Prognosis-related Factors on Their Changes after Initiating Tofogliflozin Treatment: A Retrospective Study in Japanese Patients with Type 2 Diabetes and Renal Impairment

Table 1. Clinical Background of the Study Population at Baseline.

From: Effect of Baseline Values of Renal Prognosis-related Factors on Their Changes after Initiating Tofogliflozin Treatment: A Retrospective Study in Japanese Patients with Type 2 Diabetes and Renal Impairment

			Groups divided by eGFR at baseline
	N^†	All subjects	Normal eGFR	Low eGFR	P
	N^†	(n = 130)	(n = 87)	(n = 43)	P
Male subjects (%)	130	72	71	74	0.71
Age (years)	130	64 ± 12	61 ± 12	70 ± 10	<0.01
Duration of diabetes (years)	120	13 ± 9	11 ± 8	15 ± 10	0.03
Body weight (kg)	124	74.0 ± 14.2	74.0 ± 14.8	73.9 ± 13.1	0.85
BMI (kg/m²)	124	27.6 ± 4.8	27.6 ± 5.1	27.7 ± 4.4	0.78
Obesity (%)^††	124	69	66	74	0.37
sBP (mmHg)	122	135 ± 15	134 ± 12	139 ± 18	0.23
dBP (mmHg)	119	80 ± 13	80 ± 13	79 ± 16	0.44
uPE (mg/dL)	121	36 ± 77	21 ± 49	66 ± 109	<0.01
Hematocrit (%)	130	42.7 ± 4.1	42.6 ± 3.8	43.0 ± 4.6	0.63
Hemoglobin (g/L)	130	143 ± 15	144 ± 14	142 ± 15	0.62
sUA (μmol/L)	118	305 ± 70	297 ± 71	319 ± 67	0.12
Serum potassium (mEq/L)	129	4.4 ± 0.4	4.4 ± 0.4	4.5 ± 0.4	0.05
HbA1c (%)	129	8.4 ± 1.5	8.4 ± 1.6	8.3 1.4	0.83
HbA1c (mmol/mol)	129	67.9 ± 16.5	68.2 ± 17.0	67.1 ± 15.5	0.83
eGFR (mL/min/1.73 m²)	130	68.9 ± 21.8	80.7 ± 15.3	44.6 ± 10.4	<0.01
Minimum, maximum		23.1, 141.8	60.3, 141.8	23.1, 59.9
75th percentile, median, 25th percentile		80.8, 70.0, 52.3	85.9, 77.3, 69.9	52.4, 46.2, 38.3

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Table 2. Correlation Coefficients between Changes in Renal Prognosis-Related Factors and Corresponding Baseline Values in the Normal and Low-eGFR Groups.

	Groups divided by eGFR at baseline
	Normal-eGFR		Low-eGFR		P
	correlation coefficient	z	correlation coefficient	z
Hematocrit	−0.14	−0.14	−0.39	−0.41	0.16
Hemoglobin	−0.02	−0.02	−0.36	−0.38	0.06
sBP	−0.45	−0.48	−0.57	−0.65	0.41
uPE	−0.85	−1.26	−0.81	−1.13	0.52
sUA	−0.46	−0.50	−0.63	−0.74	0.22
HbA1c	−0.77	−1.02	−0.57	−0.65	0.05
eGFR	−0.18	−0.18	0.02	0.02	0.29

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