Table 1. Patient Characteristics.

From: Asymptomatic Common Bile Duct Stones Are Associated with Increased Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Category Asymptomatic (n = 32) Symptomatic (n = 270) p value
Female sex (%) 11 (34.4) 121 (44.8) 0.35*
Age < 55 years (%) 0 36 (13.3) 0.02
Maximum Stone Diameter ≥ 10 mm (%) 7 (21.9) 65 (24.1) 1
Number of Stones ≥ 2 (%) 15 (46.9) 135 (50) 0.85
Diameter of Common Bile Duct < 10 mm (%) 20 (62.5) 184 (68.1) 0.55
Serum Bilirubin < 1.5 mg/dL (%) 28 (87.5) 132 (48.9) < 0.001
No Pre-Procedural Diclofenac (%) 28 (87.5) 237 (87.8) 1
Precut Sphincterotomy (%) 2 (6.3) 10 (3.7) 0.37
Deep Cannulation Time ≥ 10 min (%) 10 (31.3) 105 (38.9) 0.447
Papillary Treatment EPBD (%) 12 (37.5) 86 (31.9) 0.55
Contrast Injection into Pancreatic Duct (%) 17 (53.1) 150 (55.6) 0.85
Pancreatic Guidewire Cannulation (%) 1 (3.1) 29 (10.7) 0.22
No Pancreatic Stent Placement (%) 32 (100) 252 (93.3) 0.23
Biliary Stenting (%) 2 (6.3) 94 (34.8) < 0.001
Total Procedural Time ≥ 30 min (%) 15 (46.9) 148 (54.8) 0.46
Complete stone removal in the first session (%) 26 (81.3) 167 (61.9) 0.03
Post ERCP Pancreatitis (%) 5 (15.6) 10 (3.7) 0.01
Table 2. Univariate Analyses to Detect Risk Factors for PEP.

From: Asymptomatic Common Bile Duct Stones Are Associated with Increased Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Variable With PEP (n = 15) Without PEP (n = 287) p value
Female Sex (%) 7 (46.7) 153 (53.3) 1
Age < 55 years (%) 2 (13.3) 34 (11.8) 0.70
Maximum Stone Diameter ≥ 10 mm (%) 2 (13.3) 70 (24.4) 0.53
Number of Stones ≥ 2 (%) 8 (53.3) 142 (49.5) 0.80
Diameter of CBD < 10 mm (%) 13 (86.7) 191 (66.6) 0.16
Serum Bilirubin < 1.5 mg/dL (%) 7 (46.7) 153 (53.3) 1
No Pre-Procedural Diclofenac (%) 13 (86.7) 252 (87.8) 1
Precut Sphincterotomy (%) 0 12 (4.2) 1
Deep Cannulation Time ≥ 10 min (%) 10 (66.7) 105 (36.6) 0.02
Papillary Treatment EPBD (%) 9 (60) 89 (31.0) 0.03
Contrast Injection into Pancreatic Duct (%) 10 (66.7) 157 (54.7) 0.43
Pancreatic Guidewire Cannulation (%) 3 (20) 27 (9.4) 0.18
No Pancreatic Stent Placement (%) 14 (93.3) 270 (97.1) 1
Biliary stenting (%) 5 (33.3) 91 (31.7) 1
Total Procedural Time ≥ 30 min (%) 8 (53.3) 155 (54.0) 1
Complete stone removal in the first session (%) 9 (60) 184 (64.1) 0.79
Asymptomatic CBDS (%) 5 (33.3) 27 (9.4) 0.01
Table 3. Multivariate Analyses to Detect Independent Risk Factors for PEP.

From: Asymptomatic Common Bile Duct Stones Are Associated with Increased Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Variable OR (95% CI) p value
Deep Cannulation Time ≥ 10 min 6.67 (1.95–22.8) < 0.001
Papillary Treatment EPBD 5.70 (1.75–18.6) < 0.001
Asymptomatic CBDS 5.49 (1.58–19.1) < 0.001
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