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Table 1. Clinical Characteristics of Patients on Antithrombotic Therapy.

From: Factors Associated with Nonachievement of Target Blood Pressure in Patients on Antithrombotic Therapy: A Real-World Study

Clinical parameters Mean ± SD, percentage, or number
Number 2201
Age (years) 74.1 ± 11.1
Male gender (%) 59.5
SBP (mmHg) 134.9 ± 17.1
DBP (mmHg) 74.1 ± 12.9
BMI (kg/m2) 25.7 ± 4.3
eGFR (mL/min/1.73 m2) 66.3 ± 22.0
Obesity (%) 56.2
Hypertension (%) 85.2
Diabetes mellitus (%) 47.8
Dyslipidemia (%) 71.5
Cerebrovascular disease (%) 46.0
Ischemic heart disease (%) 38.0
Heart failure (%) 19.4
Atrial fibrillation (%) 17.3
Chronic kidney disease (%) 43.8
Antihypertensive therapy (%) 79.7
　ACE inhibitor (%) 14.4
　ARB (%) 41.9
　CCB (%) 52.2
　Beta-blocker (%) 21.7
　Diuretics (%) 16.5
Antithrombotic therapy (%) 100
　Acetylsalicylic acid (%) 68.1
　P2Y12 receptor inhibitor (%) 18.0
　PDE-III inhibitor (%) 5.7
　Warfarin (%) 13.3
　Direct factor Xa inhibitor (%) 6.5
　Direct thrombin inhibitor (%) 2.8
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Table 2. Achievement Rates of Target Blood Pressure Value of <130/80 mmHg in Patients on Antithrombotic Therapy.

From: Factors Associated with Nonachievement of Target Blood Pressure in Patients on Antithrombotic Therapy: A Real-World Study

Variable Achievement of the target blood pressure value
Yes, n (%) No, n (%) P-value
Age 0.031
　<75 years 279 (28.2) 709 (71.8)
　≥75 years 394 (32.5) 819 (67.5)
Gender 0.008
　Male 372 (28.4) 937 (71.6)
　Female 301 (33.7) 591 (66.3)
Obesity <0.001
　Yes 317 (25.6) 920 (74.4)
　No 356 (36.9) 608 (63.1)
Diabetes mellitus 0.783
　Yes 319 (30.3) 734 (69.7)
　No 354 (30.8) 794 (69.2)
Dyslipidemia 0.049
　Yes 462 (29.4) 1112 (70.7)
　No 211 (33.7) 416 (66.4)
Cerebrovascular disease 0.693
　Yes 314 (31.0) 699 (69.0)
　No 359 (30.2) 829 (69.8)
Ischemic heart disease 0.021
　Yes 280 (33.5) 556 (66.5)
　No 393 (28.8) 972 (71.2)
Heart failure <0.001
　Yes 184 (43.2) 242 (56.8)
　No 489 (27.6) 1286 (72.5)
Atrial fibrillation 0.163
　Yes 128 (33.6) 253 (66.4)
　No 545 (30.0) 1275 (70.1)
Chronic kidney disease
　Yes 300 (31.2) 663 (68.9) 0.605
　No 373 (30.1) 865 (69.9)
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Table 3. Logistic Regression Model of Factors Associated with Nonachievement of Target Blood Pressure Control (≥130/80 mmHg) in Patients on Antithrombotic Therapy.

From: Factors Associated with Nonachievement of Target Blood Pressure in Patients on Antithrombotic Therapy: A Real-World Study

Univariate model Multivariate model
Variable Odds ratio 95% CI P-value Odds ratio 95% CI P-value
Age, ≥75 years 0.818 0.681-0.982 0.031 0.953 0.774-1.174 0.651
Male gender 1.283 1.068-1.541 0.008 1.263 1.035-1.542 0.022
Obesity 1.699 1.416-2.041 <0.001 1.703 1.399-2.075 <0.001
Diabetes mellitus 1.026 0.856-1.230 0.783 0.917 0.751-1.121 0.398
Dyslipidemia 1.221 1.000-1.487 0.049 1.241 0.987-1.558 0.064
Cerebrovascular disease 0.964 0.803-1.156 0.693 0.748 0.600-0.932 0.010
Ischemic heart disease 0.803 0.667-0.967 0.021 0.737 0.587-0.927 0.009
Heart failure 0.500 0.402-0.622 <0.001 0.493 0.385-0.631 <0.001
Atrial fibrillation 0.845 0.669-1.071 0.163 0.916 0.696-1.208 0.531
eGFR (mL/min/1.73 m2) 1.004 1.000-1.008 0.081 1.002 0.997-1.007 0.400
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Table 4. Logistic Regression Model of Factors Associated with Nonachievement of Target Blood Pressure Control (≥130/80 mmHg) in Patients with Atrial Fibrillation on Antithrombotic Therapy.

From: Factors Associated with Nonachievement of Target Blood Pressure in Patients on Antithrombotic Therapy: A Real-World Study

Univariate model Multivariate model
Variable Odds ratio 95% CI P-value Odds ratio 95% CI P-value
Age, ≥75 years 0.795 0.515-1.221 0.296 0.947 0.568-1.578 0.835
Male gender 1.593 1.035-2.455 0.034 1.462 0.914-2.341 0.113
Obesity 1.959 1.268-3.027 0.002 2.050 1.278-3.301 0.003
Diabetes mellitus 1.221 0.792-1.896 0.367 0.909 0.557-1.485 0.703
Dyslipidemia 1.359 0.888-2.087 0.158 1.433 0.862-2.397 0.165
Cerebrovascular disease 0.727 0.442-1.207 0.215 0.643 0.373-1.112 0.114
Ischemic heart disease 0.884 0.550-1.433 0.612 0.873 0.502-1.531 0.634
Heart failure 0.446 0.288-0.688 <0.001 0.419 0.257-0.676 <0.001
eGFR (mL/min/1.73 m2) 1.002 0.991-1.013 0.752 0.997 0.985-1.009 0.613
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Table 5. Logistic Regression Model of Factors Associated with Nonachievement of Target Blood Pressure Control (≥130/80 mmHg) in Patients without Atrial Fibrillation on Antithrombotic Therapy.

From: Factors Associated with Nonachievement of Target Blood Pressure in Patients on Antithrombotic Therapy: A Real-World Study

Univariate model Multivariate model
Variable Odds ratio 95% CI P-value Odds ratio 95% CI P-value
Age, ≥75 years 0.824 0.672-1.008 0.060 0.945 0.751-1.189 0.631
Male gender 1.224 0.998-1.499 0.052 1.225 0.981-1.528 0.073
Obesity 1.668 1.363-2.042 <0.001 1.638 1.319-2.036 <0.001
Diabetes mellitus 0.978 0.800-1.196 0.830 0.919 0.737-1.145 0.451
Dyslipidemia 1.148 0.909-1.446 0.245 1.174 0.905-1.520 0.224
Cerebrovascular disease 0.971 0.794-1.187 0.774 0.755 0.589-0.966 0.025
Ischemic heart disease 0.773 0.631-0.947 0.013 0.717 0.554-0.927 0.011
Heart failure 0.519 0.399-0.677 <0.001 0.517 0.387-0.691 <0.001
eGFR (mL/min/1.73 m2) 1.004 0.999-1.009 0.099 1.003 0.998-1.008 0.281
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