Table 1. Patients’ Background Characteristics.

From: External Validation of a Prognostic Model Predicting Metastatic Castration-Resistant Prostate Cancer Survival in Patients Receiving Post-Docetaxel Second-Line Chemotherapy

All patients (n=66)
Median age (IQR), years 73 (67-76)
Biopsy Gleason Score, n (%)
 ≤7 11 (17.4)
 8 11 (17.4)
 ≥9 41 (65.2)
 NA 3
Prior local therapy, n (%)
 Presence 19 (28.8)
 Absence 47 (71.2)
Measurable disease, n (%) 46 (69.7%)
Pain, n (%) 30 (45.4%)
Progression on docetaxel <6 months, n (%) 54 (81.8)
Number of docetaxel cycles, median (IQR) 7 (5-10)
Prior treatment for CRPC, n (%)
 Abiraterone/Enzalutamide 56 (84.5)
 Radium-223 4 (6.06)
Performance status
 0 43 (65.1%)
 1 15 (22.7%)
 2 8 (12.2%)
Median time on hormone treatment (IQR), years 3.54 (2.23-6.74)
Median hemoglobin (IQR), g/dL 12.1 (10.9-12.9)
Median alkaline phosphatase (IQR), IU/L 288 (204-496)
Median PSA (IQR), ng/mL 59.1 (18.1-176.4)
Metastatic sites, n (%)
 Bone 58 (87.8)
 Lymph node 39 (59.1)
 Visceral 18 (27.2%)
Number of cabazitaxel cycles, median (IQR) 5 (3-8)
Table 2. AUC Calculations for Groups at Various Time Intervals, Including the Number of Patients Who Died or Progressed at Each Time Point.

From: External Validation of a Prognostic Model Predicting Metastatic Castration-Resistant Prostate Cancer Survival in Patients Receiving Post-Docetaxel Second-Line Chemotherapy

OS PFS
Two-risk group Three-risk group Two-risk group Three-risk group
Time point (months) Death, n (%) AUC (95% CI) AUC (95% CI) Progression, n (%) AUC (95% CI) AUC (95% CI)
12 33 (50.0) 0.67 (0.59-0.75) 0.64 (0.54-0.73) 43 (76.7) 0.63 (0.54-0.69) 0.65 (0.53-0.73)
15 40 (60.6) 0.70 (0.63-0.76) 0.67 (0.61-0.75) 45 (80.3) 0.62 (0.54-0.69) 0.64 (0.58-0.74)
18 41 (62.1) 0.71 (0.63-0.76) 0.68 (0.62-0.75) 46 (82.1) 0.62 (0.56-0.69) 0.65 (0.59-0.70)
24 42 (63.6) 0.71 (0.64-0.76) 0.69 (0.62-0.76) 47 (83.9) 0.63 (0.56-0.70) 0.65 (0.60-0.71)
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