From: Effect of Pemafibrate on Serum Creatinine in Patients with Chronic Kidney Disease
All | Fibrate naïve | Treated with fibrates | p values | |
---|---|---|---|---|
(n = 39) | (n = 23) | (n = 16) | ||
Age (y.o.) | 65 ± 10 | 67 ± 9 | 63 ± 12 | 0.19 |
Male (n(%)) | 31 (79.5) | 17 (73.9) | 14 (87.5) | 0.432 |
CKD Stage 3a (n(%)) | 19 (48.7) | 11 (47.8) | 8 (50.0) | 1.0 |
CKD Stage 3b (n(%)) | 17 (43.6) | 10 (43.4) | 7 (43.8) | 1.0 |
CKD stage 4 (n(%)) | 3 (7.7) | 2 (8.7) | 1 (6.3) | 1.0 |
Diabetes Mellitus (n(%)) | 14 (36.9) | 6 (26.1) | 8 (50.0) | 0.23 |
Hypertension (n(%)) | 35 (89.7) | 20 (87.0) | 15 (93,7) | 0.88 |
CVD (n(%)) | 5 (12.8) | 3 (13.0) | 2 (12.5) | 1.0 |
Body weight (kg) | 74.7 ± 13.2 | 74.3 ± 11.7 | 75.2 ± 15.5 | 0.84 |
BMI (kg/m2) | 27.0 ± 4.0 | 27.2 ± 4.0 | 26.6 ± 4.2 | 0.67 |
Systolic blood pressure (mmHg) | 131 ± 14.8 | 131 ± 14.5 | 132 ± 15.7 | 0.89 |
Serum creatinine (mg/dL) | 1.26 ± 0.32 | 1.22 ± 0.29 | 1.32 ± 0.36 | 0.36 |
eGFR (mL/min/1.73 m2) | 45.5 + 10.4 | 45.7 + 10.9 | 45.2 + 9.9 | 0.87 |
Triglyceride (mg/dL) | 322 [206, 438] | 380 [308, 455] | 202 [170, 304] | 0.001 |
Total cholesterol (mg/dL) | 200 + 37.6 | 206 + 42.1 | 191 + 29.6 | 0.24 |
LDL-cholesterol (mg/dL) | 107.4 + 26.7 | 106.1 + 28.9 | 109.2 + 24.1 | 0.73 |
HDL-cholesterol (mg/dL) | 45.0 + 9.3 | 45.0 + 8.0 | 45.0 + 11.2 | 1.0 |
Treatment with bezafibrate (n(%)) | 3 (18.8) | |||
Treatment with fenofibrate (n(%)) | 13 (81.2) | |||
Treatment with statins (n(%)) | 17 (43.6) | 10 (43.4) | 7 (43.8) |
From: Effect of Pemafibrate on Serum Creatinine in Patients with Chronic Kidney Disease
Baseline | After treatment | p values | ||
---|---|---|---|---|
AST (U/L) | 23.5 [20.0, 33.5] | 26.5 [21.0, 31.0] | 0.94 | |
ALT (U/L) | 24.5 [18.3, 47.0] | 25.5 [15.5, 36.3] | 0.006 | |
g-GTP (U/L) | 43.0 [25.0, 73.5] | 25.5 [22.0, 53.3] | 0.00001 | |
Total cholesterol (mg/dL) | 199.6 ± 37.6 | 192.1 ± 25.9 | 0.17 | |
LDL-cholesterol (mg/dL) | 107.4 ± 26.7 | 108.4 ± 20.0 | 0.82 | |
HDL-cholesterol (mg/dL) | 45.0 ± 9.3 | 52.7 ± 11.3 | <0.00001 | |
Triglyceride (mg/dL) | 322 [206, 438] | 188 [151, 232] | <0.00001 |