eGFR category (mL/min/1.73 m2) | ≥90 | 60-89 | 45-59 | <45 | |
---|---|---|---|---|---|
Men | |||||
Study size | (Persons) | 3,094 | 23,811 | 3,182 | 279 |
Age | (Years) | 57 ± 9 | 60 ± 10 | 66 ± 8 | 69 ± 7 |
Body mass index | (kg/m2) | 22.6 ± 2.9 | 23.3 ± 2.9 | 23.9 ± 3.0 | 23.7 ± 3.1 |
Systolic blood pressure | (mmHg) | 135 ± 18 | 136 ± 17 | 140 ± 17 | 144 ± 19 |
Diastolic blood pressure | (mmHg) | 80 ± 11 | 81 ± 11 | 82 ± 12 | 83 ± 12 |
Use of anti-hypertensive drugs | (%) | 13.3 | 18.1 | 34.2 | 52.3 |
Use of hypoglycemic drugs | (%) | 2.7 | 3.5 | 5.6 | 10.0 |
Total cholesterol | (mg/dL) | 189 ± 35 | 193 ± 35 | 197 ± 35 | 193 ± 39 |
High-density lipoprotein | (mg/dL) | 54.1 ± 15.5 | 54.1 ± 15.5 | 50.3 ± 15.5 | 46.4 ± 15.5 |
Use of lipid-lowering drugs | (%) | 0.7 | 1.1 | 2.2 | 3.2 |
Current Smoking | (%) | 43.6 | 36.5 | 24.5 | 20.1 |
Follow-up range | (Years) | 0.2-25.7 | 0.1-25.7 | 0.1-25.7 | 0.3-25.7 |
Follow-up | (Person-years) | 63,908 | 473,194 | 56,646 | 3,697 |
Women | |||||
Study size | (Persons) | 3,831 | 43,809 | 10,982 | 562 |
Age | (Years) | 54 ± 10 | 56 ± 10 | 66 ± 7 | 68 ± 8 |
Body mass index | (kg/m2) | 23.2 ± 3.2 | 23.5 ± 3.2 | 24.0 ± 3.3 | 24.2 ± 3.6 |
Systolic blood pressure | (mmHg) | 129 ± 18 | 131 ± 18 | 137 ± 17 | 141 ± 18 |
Diastolic blood pressure | (mmHg) | 76 ± 10 | 78 ± 11 | 79 ± 10 | 80 ± 11 |
Use of anti-hypertensive drugs | (%) | 10.8 | 15.7 | 35.4 | 51.8 |
Use of hypoglycemic drugs | (%) | 1.6 | 1.8 | 3.6 | 5.7 |
Total cholesterol | (mg/dL) | 201 ± 35 | 205 ± 35 | 213 ± 35 | 213 ± 43 |
High-density lipoprotein | (mg/dL) | 58.0 ± 15.5 | 58.0 ± 15.5 | 54.1 ± 15.5 | 50.3 ± 15.5 |
Use of lipid-lowering drugs | (%) | 2.1 | 2.8 | 5.2 | 4.3 |
Current smoker | (%) | 2.0 | 1.8 | 1.1 | 1.1 |
Follow-up range | (Years) | 0.1-25.7 | 0.1-25.7 | 0.1-25.7 | 0.4-25.7 |
Follow-up | (Person-years) | 86,119 | 973,528 | 220,235 | 8,649 |
eGFR, mL/min/1.73 m2 | ≥90 | 60-89 | 45-59 | <45 |
---|---|---|---|---|
Population | 6,925 | 67,620 | 14,164 | 732 |
Mean follow-up length, years | 21.7 | 21.4 | 19.5 | 14.7 |
Total mortalities | 2,318 | 22,094 | 7,548 | 654 |
Cancer mortalities | 779 | 6,986 | 1,799 | 112 |
Cancer death rate, per 10,000 person-years | 51.9 | 48.3 | 65.0 | 90.7 |
Age- and sex-adjusted HR (95%CI) | 1.14 (1.06-1.23) | Reference | 0.98 (0.93-1.03) | 1.15 (0.95-1.39) |
Multivariable-adjusted HR (95%CI) | 1.10 (1.02-1.18) | Reference | 0.98 (0.93-1.03) | 1.14 (0.94-1.37) |