Figure and Table | High Estimated Glomerular Filtration Rate and Risk of Cancer Mortality in a Japanese Cohort Study: The Ibaraki Prefectural Health Study

Table 1. Characteristics of the Study Cohort at Baseline.

eGFR category (mL/min/1.73 m²)		≥90	60-89	45-59	<45
Men
Study size	(Persons)	3,094	23,811	3,182	279
Age	(Years)	57 ± 9	60 ± 10	66 ± 8	69 ± 7
Body mass index	(kg/m²)	22.6 ± 2.9	23.3 ± 2.9	23.9 ± 3.0	23.7 ± 3.1
Systolic blood pressure	(mmHg)	135 ± 18	136 ± 17	140 ± 17	144 ± 19
Diastolic blood pressure	(mmHg)	80 ± 11	81 ± 11	82 ± 12	83 ± 12
Use of anti-hypertensive drugs	(%)	13.3	18.1	34.2	52.3
Use of hypoglycemic drugs	(%)	2.7	3.5	5.6	10.0
Total cholesterol	(mg/dL)	189 ± 35	193 ± 35	197 ± 35	193 ± 39
High-density lipoprotein	(mg/dL)	54.1 ± 15.5	54.1 ± 15.5	50.3 ± 15.5	46.4 ± 15.5
Use of lipid-lowering drugs	(%)	0.7	1.1	2.2	3.2
Current Smoking	(%)	43.6	36.5	24.5	20.1
Follow-up range	(Years)	0.2-25.7	0.1-25.7	0.1-25.7	0.3-25.7
Follow-up	(Person-years)	63,908	473,194	56,646	3,697
Women
Study size	(Persons)	3,831	43,809	10,982	562
Age	(Years)	54 ± 10	56 ± 10	66 ± 7	68 ± 8
Body mass index	(kg/m²)	23.2 ± 3.2	23.5 ± 3.2	24.0 ± 3.3	24.2 ± 3.6
Systolic blood pressure	(mmHg)	129 ± 18	131 ± 18	137 ± 17	141 ± 18
Diastolic blood pressure	(mmHg)	76 ± 10	78 ± 11	79 ± 10	80 ± 11
Use of anti-hypertensive drugs	(%)	10.8	15.7	35.4	51.8
Use of hypoglycemic drugs	(%)	1.6	1.8	3.6	5.7
Total cholesterol	(mg/dL)	201 ± 35	205 ± 35	213 ± 35	213 ± 43
High-density lipoprotein	(mg/dL)	58.0 ± 15.5	58.0 ± 15.5	54.1 ± 15.5	50.3 ± 15.5
Use of lipid-lowering drugs	(%)	2.1	2.8	5.2	4.3
Current smoker	(%)	2.0	1.8	1.1	1.1
Follow-up range	(Years)	0.1-25.7	0.1-25.7	0.1-25.7	0.4-25.7
Follow-up	(Person-years)	86,119	973,528	220,235	8,649

Table 2. Numbers and Hazard Ratios of Cancer Mortalities among Different Grades of Renal Function.

eGFR, mL/min/1.73 m²	≥90	60-89	45-59	<45
Population	6,925	67,620	14,164	732
Mean follow-up length, years	21.7	21.4	19.5	14.7
Total mortalities	2,318	22,094	7,548	654
Cancer mortalities	779	6,986	1,799	112
Cancer death rate, per 10,000 person-years	51.9	48.3	65.0	90.7
Age- and sex-adjusted HR (95%CI)	1.14 (1.06-1.23)	Reference	0.98 (0.93-1.03)	1.15 (0.95-1.39)
Multivariable-adjusted HR (95%CI)	1.10 (1.02-1.18)	Reference	0.98 (0.93-1.03)	1.14 (0.94-1.37)