Figure and Table | Managing Seroma Formation Post Breast Surgery through Somatostatin Analogs

Table 1. Approved Somatostatin Analogs in Japan.

Drug	Administration	Mechanism of action	Indications per label
Octreotide	Subcutaneous injection	High affinity for SSTR2 and inhibits the proliferation of the cells expressing SSTR2 gene by activating the tyrosine phosphatase pathway	Gastrointestinal hormone-producing tumors (VIP-producing tumors, carcinoid tumors with carcinoid syndrome, gastrin-producing tumors) Acromegaly and pituitary gigantism Improvement of gastrointestinal symptoms associated with gastrointestinal obstruction in palliative care for patients with advanced or recurrent cancer Hypoglycemia associated with congenital hyperinsulinemia
Octreotide LAR	Intramuscular injection		Gastrointestinal hormone-producing tumors (VIP-producing tumors, carcinoid tumors with carcinoid syndrome, gastrin-producing tumors) Acromegaly and pituitary gigantism Hypoglycemia associated with congenital hyperinsulinemia
Lanreotide	Subcutaneous injection	A cyclic octapeptide that was developed with the intent to achieve a longer acting analog	Acromegaly and pituitary gigantism Thyroid-stimulating hormone-producing pituitary tumor
Pasireotide LAR	Intramuscular injection	High affinity to SSTR1, SSTR3, and SSTR5 and with the same affinity to SST2 with octreotide	Cushing Disease