Table 1. Comparison between Patients with NF1 with and without Restricted Medical Access.

From: Real-world Settings for the Surgical Treatment of Neurofibroma in Patients with Neurofibromatosis Type 1

Parameters Non-restricted Restricted p-value
Mean age ± standard deviation (years) 46.3 ± 14.0 43.7 ± 14.3 0.065
Sex distribution 0.346
 Male 119 50
 Female 141 73
D-classification in each patient <0.001*
 D1 3 5
 D2 62 58
 D3 130 38
 D4 65 22
N-classification in each patient 0.855
 N0 175 86
 N1 77 34
 N2 8 3
B-classification in each patientǂ 0.440
 B0 167 81
 B1 68 34
 B2 25 7
Type of excised neurofibroma in each patient
 Cutaneous neurofibroma 230/260 (88.5%) 120/123 (97.6%) 0.003*
 Nodular plexiform neurofibroma 21/260 (8.1%) 5/123 (4.1%) 0.145
 Diffuse plexiform neurofibroma 23/260 (8.8%) 3/123 (2.4%) 0.020*
Site of excised neurofibroma in each patient
 Head/Neck 94/260 (36.2%) 41/123 (33.3%) 0.590
 Trunk 146/260 (56.2%) 74/123 (60.2%) 0.459
 Arm/Leg 100/260 (38.5%) 44/123 (35.8%) 0.612
 Hand/Foot 29/260 (11.2%) 21/123 (17.1%) 0.108
Number of excised neurofibromas in each patient§ 0.699
 1 42 16
 2−9 159 79
 ≥10 58 26
Reason to undergo surgery in each patient (multiple selection allowed)
 Cosmetic disturbance 46/260 (17.7%) 8/123 (6.5%) 0.003*
 Pain of tumor 58/260 (22.3%) 15/123 (12.2%) 0.019*
 Itch of tumor 2/260 (0.8%) 1/123 (0.8%) 0.964
 Burden of tumor 222/260 (85.4%) 112/123 (91.1%) 0.121
PAGE TOP