Table 1. Clinicopathological Characteristics of Patients with PTC with Normal and High Serum CA19-9 Levels before Surgery.

From: Availability of Serum Levels of Carbohydrate Antigen 19-9 (CA19-9) as a Surrogate Tumor Marker for Papillary Thyroid Carcinoma

Normal serum
CA19-9
High serum
CA19-9
p-value
No. of patients 184 (93.9%) 12 (6.1%)
Age, years a 47 (16-89) 38.5 (18-87) 0.531
Gender:
 Male 45 (24.5%) 3 (25.0%) 0.975
 Female 139 (75.5%) 9 (75.0%)
Max. tumor size, mm a 26 (20-110) 33 (20-61) 0.130
Anti-thyroglobulin antibody:
 Positive 32 1 0.695
 Negative 152 11
Serum thyroglobulin levels before surgery, ng/mL a,b 59.8 (2.0-2684) 122.0 (1.0-1875) 0.400
Serum thyroglobulin levels after surgery, ng/mL a,b 1.2 (0.1-185) 2.3 (0.3-377.7) 0.308
Extrathyroidal invasion:
 Positive 10 2 0.287
 Negative 174 10
Nodal metastasis:
 Positive 159 11 0.249
 Negative 25 1
Vascular invasion:
 Positive 10 1 0.512
 Negative 174 11
Lymphangial invasion:
 Positive 4 2 0.046
 Negative 180 10
Ki-67 labeling index:
 0%-5% 119 8
 5%-10% 37 2 0.567
 >10% 5 1
 Unknown 23 1
Serum level of CA19-9, U/mL: a
 Before surgery 11.2 (1-36.3) 60.5 (40.8-221) <0.01
 After surgery 9.0 (1-29.5) 32.5 (17.5-36) <0.01
Table 2. Relationship between Serum CA19-9 Levels and CA19-9 Immunostaining Results.

From: Availability of Serum Levels of Carbohydrate Antigen 19-9 (CA19-9) as a Surrogate Tumor Marker for Papillary Thyroid Carcinoma

Serum levels of CA19-9
High
>37 U/mL
Normal
≤37 U/mL
CA19-9 Positive 12 16
Immunohistochemistry Negative 0 34
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