JMA Journal

Figure 1. Number of CMBs in each anatomical area.
CMBs were common in the putamen, thalamus, and pons, as well as in the cerebral cortex. There were generally more CMBs in the temporal cortex than in other cortices. CMBs: cerebral microbleeds, LAA: large artery atherosclerosis, SVO: small vessel occlusion, CE: cardioembolism.

Figure 2. Images from a 90-year-old male with cerebral subcortical hemorrhage.
A. T2-weighted gradient echo images on cranial magnetic resonance imaging. Cerebral microbleeds (CMBs) can be seen in the temporal and occipital cortices.
B. Hematoxylin and eosin stain. Deposits of hemosiderin can be seen in the occipital lobe cortex. The accumulation of the hemosiderin deposits probably correspond to one CMB. Bar = 100 µm.
C. Berlin blue stain. Deposits of iron are present in the perivascular regions (arrow). Bar = 100 µm.
D. The vascular wall within the CMB was immunoreactive to monoclonal antibody raised against amyloid-β (11–28). Amyloid-β immunoreactive diffuse plaques are also present. Bar = 100 µm.