Figure 1. RET rearrangement is detected in papillary thyroid cancer (PTC) and non-small cell lung cancer (NSCLC). RET/PTC1 and RET/PTC3 were reported to be detected in 5%–35% of adult and 60%–70% of childhood PTCs after the Chernobyl reactor accident, respectively. KIF5B-RET was identified mainly in NSCLC. SP, signal peptide; CLD, cadherin-like domain; CRD, cysteine-rich domain; TM, transmembrane domain; TK, tyrosine kinase domain.
From: Roles of the RET Proto-oncogene in Cancer and Development