JMA Journal

Figure 1. Schematic of single-nucleotide polymorphism (SNP) types according to the location and function. UTR, untranslated region.

Figure 2. Gene function of single-nucleotide polymorphisms (SNPs) associated with therapeutic effects and adverse events of drug therapy. Underlined organs and treatments in parentheses mean target organ and treatment in which the gene function of SNPs is involved, respectively. ADT, androgen-deprivation therapy; ARPI, androgen receptor-pathway inhibitor.

Figure 3. Schematic of molecules involved in androgen synthesis and uptake. The metabolisms surrounded by red, light blue, and blue are mainly processed in adrenal glands, prostate cancer, and both, respectively. OATP2B1 uptakes DHEA into prostate cancer cells. DHEA, dehydroepiandrosterone; DHT, dihydrotestosterone.