| Liver dysfunction and/or proteinuria (+) | Obesity (−) | Obesity (+) | P value | |
|---|---|---|---|---|
| Study size | (persons) | 48,676 | 36,256 | |
| Sex | (% female) | 35.1 | 39.5 | <0.001 |
| Age | (years) | 63 ± 8 | 61 ± 8 | <0.001 |
| Body mass index | (kg/m2) | 22.1 ± 2.1 | 27.9 ± 2.6 | <0.001 |
| Systolic blood pressure | (mmHg) | 131 ± 18 | 136 ± 17 | <0.001 |
| Diastolic blood pressure | (mmHg) | 78 ± 11 | 81± 11 | <0.001 |
| Aspartate aminotransferase | (IU/L) | 35 ± 21 | 35 ± 18 | 0.004 |
| Alanine aminotransferase | (IU/L) | 34 ± 23 | 43 ± 25 | <0.001 |
| Baseline proteinuria, +/- or more | (% yes) | 31.0 | 39.9 | <0.001 |
| Estimated GFR | (mL/min/1.73 m2) | 75.4 ± 17.4 | 74.4 ± 17.2 | <0.001 |
| Free blood sugar | (mg/dL) | 101 ± 25 | 108 ± 28 | <0.001 |
| Hemoglobin A1c | (%) | 5.4 ± 0.8 | 5.7 ± 0.9 | <0.001 |
| Triglycerides | (mg/dL) | 139 ± 113 | 168 ± 116 | <0.001 |
| High-density lipoprotein | (mg/dL) | 62.3 ± 17.9 | 53.6 ± 13.3 | <0.001 |
| Low-density lipoprotein | (mg/dL) | 120 ± 34 | 129 ± 32 | <0.001 |
| Exercise habit | (% yes) | 36.4 | 42.0 | <0.001 |
| Smoking | (%) | 22.2 | 21.1 | <0.001 |
| Alcohol intake habit, daily | (% yes) | 35.4 | 36.4 | 0.003 |
| Use of antihypertensive drugs | (%) | 32.8 | 33.2 | 0.220 |
| Use of hypoglycemic drugs | (%) | 7.7 | 7.2 | 0.006 |
| Use of lipid-lowering drugs | (%) | 15.8 | 16.3 | 0.049 |
| ΔBMI | (kg/m2/year) | +0.1 ± 0.8 | -0.1 ± 1.0 | <0.001 |
| Time to endpoint | (days) | 1,088 ± 545 | 1,104 ± 549 | <0.001 |
| Improvement of liver dysfunction | Improvement of proteinuria | ||||
|---|---|---|---|---|---|
| Model 1 | Units | Age- and sex-adjusted | P value | Age- and sex-adjusted | P value |
| Sex | female | 1.07 (1.03-1.11) | <0.01 | 1.33 (1.26-1.40) | <0.01 |
| Age | per −10 years | 0.89 (0.87-0.91) | <0.01 | 1.09 (1.05-1.13) | <0.01 |
| Δ Body mass index | per −1 kg/m2/year | 1.07 (1.05-1.09) | <0.01 | 1.04 (1.02-1.07) | <0.01 |
| Model 2 | Multivariable-adjusted | P value | Multivariable-adjusted | P value | |
| Sex | female | 1.05 (1.00-1.10) | 0.06 | 1.29 (1.20-1.40) | <0.01 |
| Age | per −10 years | 0.90 (0.87-0.93) | <0.01 | 1.00 (0.95-1.04) | 0.89 |
| Δ Body mass index | per −1 kg/m2/year | 1.07 (1.05-1.09) | <0.01 | 1.04 (1.02-1.07) | <0.01 |
| Body mass index | per −1 kg/m2 | 1.01 (1.00-1.02) | 0.03 | 1.01 (1.00-1.02) | 0.08 |
| Estimated GFR | per +10 mL/min/1.73 m2 | 0.97 (0.96-0.99) | <0.01 | 1.07 (1.06-1.09) | <0.01 |
| Smoking | no current smoking | 1.01 (0.96-1.07) | 0.59 | 1.08 (0.99-1.18) | 0.07 |
| Alcohol intake habit | not daily | 1.01 (0.99-1.04) | 0.32 | 1.01 (0.97-1.06) | 0.55 |
| Systolic blood pressure | per −10 mmHg | 0.98 (0.96-1.00) | 0.01 | 1.03 (1.01-1.05) | 0.01 |
| Diastolic blood pressure | per −10 mmHg | 1.02 (0.99-1.04) | 0.14 | 0.96 (0.93-1.00) | 0.05 |
| Use of antihypertensive drugs | no use | 1.07 (1.03-1.12) | <0.01 | 1.27 (1.19-1.35) | <0.01 |
| Use of hypoglycemic drugs | no use | 0.98 (0.91-1.05) | 0.54 | 1.17 (1.05-1.30) | <0.01 |
| Use of lipid-lowering drugs | no use | 0.99 (0.94-1.04) | 0.69 | 1.10 (1.02-1.19) | 0.02 |
| Hemoglobin A1c | per −1% | 0.96 (0.94-0.99) | 0.01 | 1.09 (1.05-1.13) | <0.01 |
| Triglycerides | per −10 mg/dL | 1.00 (1.00-1.00) | <0.01 | 1.00 (1.00-1.01) | 0.01 |
| High-density lipoprotein | per −10 mg/dL | 0.99 (0.97-1.01) | 0.20 | 1.00 (0.98-1.04) | 0.42 |
| Low-density lipoprotein | per −10 mg/dL | 0.99 (0.98-0.99) | <0.01 | 1.01 (1.00-1.02) | 0.22 |
