| Total (n = 2003) | CMBs + (n = 1025) | CMBs − (n = 978) | p Value | OR | |
|---|---|---|---|---|---|
| Age (mean ± SD) | 71.8 ± 12.4 | 73.3 ± 11.6 | 70.3 ± 13.0 | < 0.001 | 1.025 |
| Male sex | 1192 (60%) | 612 (60%) | 580 (59%) | 0.022 | 1.017 |
| Alcohol | 564 (28%) | 273 (27%) | 291 (30%) | 0.256 | 0.874 |
| Smoking | 403 (20%) | 194 (19%) | 209 (21%) | 0.687 | 1.055 |
| Cognitive Impairment | 637 (32%) | 387 (38%) | 250 (26%) | < 0.001 | 1.514 |
| Hypertension | 1340 (67%) | 813 (79%) | 527 (54%) | < 0.001 | 3.145 |
| Diabetes mellitus | 531 (27%) | 258 (25%) | 273 (28%) | 0.881 | 0.983 |
| Hypercholesterolemia | 403 (20%) | 188 (18%) | 215 (22%) | 0.455 | 0.913 |
| Liver dysfunction | 287 (14%) | 152 (15%) | 135 (14%) | 0.156 | 1.222 |
| Antithrombotic medication before stroke | 543 (27%) | 233 (23%) | 180 (18%) | 0.646 | 1.073 |
| Previous history of stroke | 539 (27%) | 273 (27%) | 159 (16%) | < 0.001 | 1.782 |
| Atrial fibrillation | 403 (20%) | 168 (16%) | 235 (24%) | 0.001 | 0.654 |
| Coronary artery disease | 135 (7%) | 60 (6%) | 75 (8%) | 0.050 | 0.673 |
| Length of hospital stay (mean ± SD) | 12.6 ± 8.2 | 12.5 ± 8.3 | 12.8 ± 8.0 | 0.063 | 0.988 |
| Hemorrhagic stroke | 452 (23%) | 288 (28%) | 164 (17%) | < 0.001 | 2.066 |
| CMBs ≥ 5 (n = 558) | CMBs < 5 (n = 1445) | p Value | OR | |
|---|---|---|---|---|
| Age (mean ± SD) | 73.7 ± 11.3 | 71.1 ± 12.8 | < 0.001 | 1.016 |
| Male sex | 330 (59%) | 862 (60%) | 0.130 | 1.208 |
| Alcohol | 148 (27%) | 416 (29%) | 0.541 | 0.920 |
| Smoking | 102 (18%) | 301 (21%) | 0.893 | 1.021 |
| Cognitive Impairment | 238 (43%) | 399 (28%) | < 0.001 | 1.793 |
| Hypertension | 496 (89%) | 844 (58%) | < 0.001 | 5.487 |
| Diabetes mellitus | 132 (24%) | 399 (28%) | 0.528 | 0.921 |
| Hypercholesterolemia | 106 (19%) | 297 (21%) | 0.496 | 1.100 |
| Liver dysfunction | 83 (15%) | 204 (14%) | 0.314 | 1.174 |
| Antithrombotic medication before stroke | 138 (25%) | 275 (19%) | 0.622 | 1.086 |
| Previous history of stroke | 175 (31%) | 257 (18%) | < 0.001 | 2.166 |
| Atrial fibrillation | 72 (13%) | 331 (23%) | < 0.001 | 0.567 |
| Coronary artery disease | 31 (6%) | 104 (7%) | 0.088 | 0.664 |
| Length of hospital stay (mean ± SD) | 12.2 ± 13.7 | 12.8 ± 8.6 | 0.173 | 0.982 |
| Hemorrhagic stroke | 187 (34%) | 265 (18%) | < 0.001 | 2.424 |
| LAA (n = 546) | SVO (n = 490) | CE (n = 365) | p Value | |
|---|---|---|---|---|
| Age (mean ± SD) | 73.8 ± 11.0† | 71.7 ± 11.6 | 76.2 ± 10.6* | < 0.001 |
| Male sex | 336 (62%) | 298 (61%) | 220 (60%) | 0.918 |
| Alcohol | 148 (27%) | 146 (32%) | 103 (28%) | 0.630 |
| Smoking | 125 (23%) | 113 (23%) | 51 (14%)* | < 0.001 |
| Cognitive Impairment | 191 (35%) | 142 (29%) | 138 (38%)‡ | 0.018 |
| Hypertension | 367 (67%) | 358 (73%) | 185 (51%)* | < 0.001 |
| Diabetes mellitus | 202 (37%) | 164 (33%) | 66 (18%)* | < 0.001 |
| Hypercholesterolemia | 136 (25%) | 109 (22%) | 52 (14%)* | < 0.001 |
| Liver dysfunction | 57 (10%) | 48 (10%) | 62 (17%)* | 0.002 |
| Antithrombotic medication before stroke | 113 (21%) | 90 (18%) | 137 (38%)* | < 0.001 |
| Antiplatelet agent | 101 (18%) | 82 (17%) | 71 (19%) | |
| Anticoagulants | 14 (3%) | 10 (2%) | 74 (20%) | |
| Previous history of ischemic stroke | 109 (20%) | 93 (19%) | 91 (25%) | 0.083 |
| Previous history of hemorrhagic stroke | 26 (5%) | 23 (5%) | 6 (2%)‡ | 0.033 |
| Atrial fibrillation | 31 (6%) | 22 (4%) | 324 (89%)* | < 0.001 |
| Coronary artery disease | 47 (9%) | 17 (3%)§ | 46 (13%) | < 0.001 |
| Length of hospital stay (mean ± SD) | 12.0 ± 6.7 | 9.8 ± 4.4§ | 13.3 ± 7.5 | < 0.001 |
| CMBs presence | 268 (49%) | 282 (58%) | 142 (39%)‡ | < 0.001 |
| Antithrombotic medication | 68/268 (25%) | 58/282 (21%) | 58/142 (41%) | |
| Number of CMBs | 3,280 | 4,602 | 1,213* | < 0.001 |
| Lobar (n = 100) | Deep (n = 466) | Diffuse (n = 459) | p Value | |
|---|---|---|---|---|
| Age (mean ± SD) | 75.7 ± 12.0 | 71.8 ± 12.4* | 74.2 ± 10.5 | 0.001 |
| Male sex | 60 (60%) | 290 (62%) | 262 (57%) | 0.297 |
| Alcohol | 22 (22%) | 144 (31%)† | 107 (23%) | 0.019 |
| Smoking | 16 (16%) | 107 (23%)† | 71 (15%) | 0.011 |
| Cognitive Impairment | 41 (41%) | 128 (27%)* | 218 (47%) | < 0.001 |
| Hypertension | 65 (65%) | 346 (74%) | 401 (87%)‡ | < 0.001 |
| Diabetes mellitus | 28 (28%) | 120 (26%) | 111 (24%) | 0.661 |
| Hypercholesterolemia | 12 (12%) | 87 (19%) | 89 (19%) | 0.215 |
| Liver dysfunction | 14 (14%) | 81 (17%) | 57 (12%) | 0.105 |
| Antithrombotic medication before stroke | 33 (33%) | 115 (25%) | 144 (31%) | 0.147 |
| Previous history of stroke | 25 (25%) | 117 (25%) | 216 (47%)‡ | < 0.001 |
| Atrial fibrillation | 24 (24%) | 75 (16%) | 68 (15%) | 0.079 |
| Coronary artery disease | 8 (8%) | 26 (6%) | 26 (6%) | 0.631 |
| Length of hospital stay (mean ± SD) | 13.7 ± 11.1 | 12.5 ± 9.2 | 12.1 ± 6.2 | 0.247 |
| Number of CMBs | 860 | 2,057 | 12,932‡ | < 0.001 |
