Characteristics | Group | Frequency (%) N = 102 |
---|---|---|
Age: Mean ± SD | 49.93 ± 14.27 | |
Age group (years) | 15-29 | 10 (9.8) |
30-44 | 18 (17.6) | |
45-59 | 45 (44.1) | |
60-74 | 25 (24.5) | |
>75 | 4 (3.9) | |
Sex | Female | 74 (72.5) |
Male | 28 (27.5) | |
Occupation | Farmer | 39 (38.2) |
Housewife | 31 (30.4) | |
Business | 12 (11.8) | |
Student | 5 (4.9) | |
Service | 9 (8.8) | |
Others | 6 (5.9) | |
Marital status | Single | 93 (91.2) |
Married | 7 (6.9) | |
Divorced | 2 (2) | |
Cancer type | Breast cancer | 35 (34.3) |
Lung cancer | 15(14.7) | |
Ovarian cancer | 8 (7.8) | |
Stomach cancer | 6 (5.9) | |
Rectal cancer | 6 (5.9) | |
Cervical cancer | 4 (3.9) | |
Pancreatic Cancer | 3 (2.9) | |
Immature teratoma | 3 (2.9) | |
Urinary bladder cancer | 3 (2.9) | |
Cholangiocarcinoma | 2 (1.9) | |
Gallbladder Cancer | 2 (1.9) | |
Choriocarcinoma | 2 (1.9) | |
Non-Hodgkin lymphoma (NHL) | 2 (1.9) | |
Colon Cancer | 1 (0.9) | |
Prostate Cancer | 1 (0.9) | |
Acute lymphoblastic leukemia (ALL) | 1 (0.9) | |
Acute myeloid leukemia (AML) | 1 (0.9) | |
Hodgkin’s Lymphoma | 1 (0.9) | |
Vulval Cancer | 1 (0.9) | |
Oesophageal cancer | 1 (0.9) | |
Gestational Trophoblastic Neoplasia (GTN) | 1 (0.9) | |
Periampullary cancer | 1 (0.9) | |
Rectosigmoid cancer | 1 (0.9) | |
Endometrial cancer | 1 (0.9) | |
Stage of cancer | I | 7 (6.9) |
II | 28 (27.5) | |
III | 25 (24.5) | |
IV | 25 (24.5) | |
Stage not defined | 17 (16.6) | |
Chemotherapy cycle | Second | 19 (18.6) |
Third | 28 (27.5) | |
Fourth | 14 (13.7) | |
Fifth | 20 (19.6) | |
Sixth | 12 (11.8) | |
Seventh | 3 (2.9) | |
Ninth | 4 (3.9) | |
Others | 2 (2) |
Cancer type | ADR frequency (%) (N=861) |
---|---|
Breast cancer | 304 (35.3) |
Lung cancer | 100 (11.6) |
Ovarian cancer | 65 (7.5) |
Stomach cancer | 52 (6.0) |
Rectal cancer | 51 (5.9) |
Cervical cancer | 35 (4.0) |
Pancreatic cancer | 15 (1.7) |
Urinary bladder cancer | 26 (3.0) |
Immature teratoma | 26 (3.0) |
Non-Hodgkin lymphoma (NHL) | 21 (2.4) |
Cholangiocarcinoma | 22 (2.5) |
Others* | 144 (16.8) |
Pattern of Adverse drug reactions | Frequency (%) (N=102) |
---|---|
Fatigue | 86 (84.3) |
Anorexia | 81 (79.4) |
Alopecia | 65 (63.7) |
Constipation | 44 (43.1) |
Nausea | 43 (42.1) |
Neutropenia | 42 (41.1) |
Anemia | 41 (40.2) |
Vomiting | 40 (39.2) |
Neuropathy | 37 (36.2) |
Injection site reaction | 32 (31.3) |
Nail changes | 27 (26.4) |
Malaise | 26 (25.4) |
Edema | 23 (22.5) |
Taste changes | 14 (13.7) |
Weight changes | 16 (15.6) |
Diarrhea | 17 (16.6) |
Fever | 19 (18.6) |
Hyperpigmentation | 14 (13.7) |
Dyspepsia | 13 (12.7) |
Febrile neutropenia | 10 (9.8) |
Blood pressure changes | 9 (8.8) |
Burning micturition | 9 (8.8) |
Dyspnea | 9 (8.8) |
Thrombocytopenia | 8 (7.8) |
Irregular menses | 7 (6.8) |
Joint pain | 7 (6.8) |
Insomnia | 7 (6.8) |
Anaphylaxis | 5 (4.9) |
Difficulty swallowing | 5 (4.9) |
Infection | 6 (5.8) |
Irritability | 5 (4.9) |
Flatulence | 5 (4.9) |
Cough | 4 (3.9) |
Eye problems | 2 (1.9) |
Anticancer drugs | Frequency (%) (N=861) |
---|---|
Cyclophosphamide | 347 (40.3) |
5-fluorouracil | 284 (32.9) |
Carboplatin | 266 (30.9) |
Gemcitabine | 177 (20.5) |
Docetaxel | 176 (20.4) |
Doxorubicin | 166 (19.2) |
Epirubicin | 145 (16.8) |
Cisplatin | 115 (13.3) |
Etoposide | 92 (10.6) |
Paclitaxel | 88 (10.2) |
Oxaliplatin | 60 (6.9) |
Vincristine | 54 (6.2) |
Methotrexate | 53 (6.1) |
Bleomycin | 44 (5.1) |
Actinomycin | 36 (4.1) |
Vinblastine | 18 (2.0) |
Others | 44 (5.1) |
Class | Frequency (%) N=102 |
---|---|
Proton Pump Inhibitors | 102 (100.0) |
IV Normal Saline flush | 102 (100.0) |
Anti-emetics | 102 (100.0) |
Protein powder | 89 (87.2) |
Mouth Gargle | 78 (76.4) |
Iron tablets | 72 (70.5) |
Inj. Granulocyte colony-stimulating factor | 68 (66.6) |
Multivitamin mineral tablets | 57 (55.8) |
Analgesics | 34 (33.3) |
Antimicrobial agents | 27 (26.4) |
Laxatives | 25 (24.5) |
Corticosteroids | 24 (23.5) |
Appetite stimulant | 23 (22.5) |
IV mannitol, Potassium Chloride, Magnesium Sulphate | 15 (14.7) |
Probiotics | 13 (12.7) |
Folinic acid | 13 (12.7) |
Pregabalin and Vitamin B-12 | 10 (9.8) |
Antacid suspension | 7 (6.8) |
Antispasmodic | 6 (5.8) |
Antipsychotic | 5 (4.9) |
Anti-diarrheal agents | 4 (3.9) |
Antihistamines | 2 (1.9) |