From: Pregnancy Outcomes in Women with Thyroid Diseases
Control (n = 3531) | Hyperthyroidism (n = 48) | Hypothyroidism (n = 61) | p Value | |
---|---|---|---|---|
Baseline characteristics | ||||
Maternal age, years | 33 (15-52) | 33 (25-42) | 33 (22-43) | 0.102 |
<20 years | 33 (0.9) | 0 (0.0) | 0 (0.0) | |
20-35 years | 2241 (63.5) | 29 (60.4) | 37 (60.7) | 0.907 |
≥35 years | 1257 (35.6) | 19 (39.6) | 24 (39.3) | |
Nulliparity | 1959 (55.5) | 31 (64.5) | 38 (62.3) | 0.262 |
ART | 314 (8.9) | 4 (8.3) | 12 (19.7) | 0.026* |
Hypertension | 28 (0.8) | 0 (0.0) | 0 (0.0) | 1.00 |
DM | 79 (2.2) | 1 (2.1) | 1 (3.3) | 0.661 |
Psychiatric disease | 190 (5.4) | 1 (2.1) | 4 (6.6) | 0.617 |
Pregnancy outcomes | ||||
Gestatinal weeks at birth | 38.7 (22.4-42.6) | 39.4 (33.1-41.3) | 39.3 (32.6-42.0) | 0.015* |
Birth Weight (g) | 2906 (270-4648) | 2950 (1610-3812) | 3014 (1226-3714) | 0.259 |
Malposition at delivery | 270 (7.7) | 1 (2.1) | 4 (6.6) | 0.421 |
Cesarean section | 1461 (41.4) | 17 (35.4) | 25 (41.0) | 0.737 |
Emergent cesarean section | 590 (16.7) | 10 (20.9) | 13 (21.3) | 0.453 |
Vacuum or Foreceps | 367 (7.6) | 7 (14.6) | 5 (8.2) | 0.178 |
Apgar Score ≤6 at 1 min | 368 (10.4) | 2 (4.2) | 1 (1.6) | 0.020* |
Apgar Score ≤6 at 5 min | 196 (5.6) | 0 (0.0) | 0 (0.0) | 0.031* |
Preterm labor | 376 (10.7) | 5 (10.4) | 6 (9.8) | 1.000 |
Preeclampsia | 156 (4.4) | 5 (10.4) | 3 (4.9) | 0.124 |
LFD infants‡ | 340 (9.7) | 6 (12.5) | 5 (8.3) | 0.708 |
PROM | 148 (4.2) | 1 (2.1) | 3 (4.9) | 0.796 |
Placenta previa | 149 (4.2) | 1 (2.1) | 0 (0.0) | 0.264 |
Placenta abruption | 16 (0.5) | 2 (4.2) | 0 (0.0) | 0.032* |
Preterm birth | 507 (14.4) | 5 (10.4) | 3 (4.9) | 0.072 |
From: Pregnancy Outcomes in Women with Thyroid Diseases
Univariable analysis | Multivariable analysis | |||||
---|---|---|---|---|---|---|
Crude OR | 95%CI | p value | aOR | 95%CI | p value | |
Maternal age (years) | 0.957 | 0.869-1.049 | 0.357 | |||
Nulliparity | 0.793 | 0.314-2.00 | 0.625 | |||
Hyperthyroidism | 9.71 | 2.17-43.48 | <0.01* | 8.21 | 1.76-38.34 | <0.01* |
Preeclampsia | 4.30 | 1.23-15.00 | 0.022* | 4.10 | 1.13-14.76 | 0.031* |
Preterm labor | 3.26 | 1.15-9.20 | 0.025* | 3.38 | 1.19-9.64 | 0.023* |
Placenta previa | 1.37 | 0.18-10.37 | 0.760 | |||
LFD infants | 2.68 | 0.88-8.21 | 0.083 |