Figure and Table | Obesity Is a Risk Factor for Renal Dysfunction Following Persistent Proteinuria: An Observational Cohort Study

Table 1. Baseline Data of the Subjects with and without Renal Events.

	No event	Proteinuria or low eGFR		Proteinuria and low eGFR
	Without proteinuria or low eGFR	Low eGFR alone	Proteinuria alone	Proteinuria following low eGFR	Low eGFR following proteinuria	Simultaneous proteinuria and low eGFR
Number	37276	3553	190	43	64	16
Women, %	33.4	25.5	16.3	11.6	12.5	6.3
Age, y	42 ± 9	44 ± 9	43 ± 8	46 ± 8 *	44 ± 8	44 ± 10
Height, cm	165.6 ± 5.8	166.4 ± 8.2	166.7 ± 7.4	167.8 ± 8.0	166.1 ± 6.6	166.2 ± 7.1
Weight, cm	62.3 ± 11.6	63.9 ± 10.6	68.1 ± 15.0***	67.0 ± 11.4*	68.7 ± 12.4***	73.8 ± 17.1
BMI, kg/m²	22.7 ± 3.4	23.0 ± 2.9	24.4 ± 4.5***	23.7 ± 2.9	24.8 ± 3.5***	26.5 ± 4.6*
FBS, mg/dL	98 ± 15	100 ± 13	110 ± 31***	106 ± 12***	111 ± 30**	127 ± 53
SBP, mmHg	120 ± 15	122 ± 16	129 ± 18***	133 ± 19***	131 ± 17***	135 ± 25
DBP, mmHg	72 ± 11	74 ± 10	77 ± 12***	79 ± 13**	79 ± 12***	81 ± 18
T-CHO, mg/dL	193 ± 33	194 ± 34	201 ± 34**	200 ± 37	201 ± 34	195 ± 27
TG, mg/dL	107 ± 75	119 ± 91	153 ± 106***	130 ± 65	149 ± 126*	165 ± 132
Follow-up Duration, y	9.5 ± 7.0	16.8 ± 7.3	15.5 ± 7.4***	19.7 ± 6.4***	19.5 ± 6.9***	15.9 ± 7.4*

Table 2. Risk Factors for Renal Events with Proteinuria and Low eGFR.

Factor	Risk for renal outcomes, odds ratio (95% confidence interval)
	Proteinuria or low eGFR		Proteinuria and low eGFR
	Low eGFR alone (N = 3553)	Proteinuria alone (N = 190)	Proteinuria following low eGFR (N = 43)	Low eGFR following proteinuria (N = 64)	Simultaneous proteinuria and low eGFR (N = 16)
Sex, women	0.75 (0.69-0.81)***	0.54 (0.36-0.81)***	0.31 (0.12-0.88)*	0.41 (0.19-0.87)*	0.23 (0.03-1.75)
Age, +10 y	1.19 (1.14-1.23)***	1.00 (0.83-1.17)	1.47 (1.09-1.86)*	1.00 (0.72-1.30)	1.05 (0.50-1.63)
FBS, +10 mg/dL	1.00 (0.98-1.03)	1.14 (1.10-1.19)***	1.07 (0.93-1.21)	1.14 (1.07-1.22)***	1.23 (1.13-1.32)***
SBP, +10 mmHg	1.07 (1.03-1.11)**	1.31 (1.15-1.48)***	1.53 (1.22-1.85)**	1.42 (1.15-1.69)**	1.41 (0.89-1.96)
DBP, +10 mmHg	0.96 (0.90-1.02)	0.87 (0.63-1.12)	0.72 (0.26-1.19)	0.85 (0.45-1.26)	0.99 (0.21-1.84)
T-CHO, +10 mg/dL	0.99 (0.98-1.00)	1.01 (0.97-1.06)	1.02 (0.93-1.12)	1.02 (0.94-1.09)	0.93 (0.78-1.09)
TG, +10 mg/dL	1.01 (1.01-1.02)**	1.02 (1.01-1.03)***	1.00 (0.97-1.04)	1.01 (1.00-1.03)	1.02 (0.99-1.05)
Low BMI, <18.5 kg/m²	0.66 (0.55-0.79)***	1.10 (0.53-2.29)	0.61 (0.08-4.55)	0.48 (0.07-3.53)	nil
High BMI, >25.0 kg/m²	0.96 (0.88-1.05)	1.42 (1.02-1.96)*	0.85 (0.41-1.76)	1.99 (1.17-3.39)*	2.68 (0.93-7.75)